# Core 1 Training pp.332-366

> **NIH NIH P41** · ILLINOIS INSTITUTE OF TECHNOLOGY · 2020 · $25,293

## Abstract

The BioCAT Biotechnology Research Resource operates X-ray beamline 18ID at the Advanced Photon 
Source, Argonne National Laboratory. Now in its 20th year of operation, it is a mature, productive facility with 
many capabilities unique in the USA, and, arguably, the world. Going forward, we intend to maintain our world- 
class capabilities in static, time- and spatially-resolved fiber diffraction with beamline enhancements for 
increased flux and beam quality. A novel high speed, high sensitivity, high spatial resolution pixel array 
detector will provide an excellent match to the needs of our muscle diffraction program. Also proposed is a 
versatile micro-diffraction/micro-SAXS instrument that can use one of two Compound Refractive Lenses 
optimized for either wide- or small-angle fiber crystallography, and continuous flow SAXS experiments. We will 
implement multimodal scanning micro-diffraction, x-ray florescence microscopy, phase contrast and uv/visible 
imaging that can be done either singly or in combination with the same instrument on the same samples. 
Developments in time-resolved SAXS will extend available time regimes from 500 ns to seconds with major 
reductions in sample consumption, by more than order of magnitude, from current capabilities. This will allow 
a much wider range of biomedical problems to be addressed than previously possible. A new beamline data 
acquisition and control system will provide a common interface and better data management for all 
experiments and advanced support for time resolved experiments. Combined refractive index, dynamic light 
scattering and multi-angle light scattering measurements with SAXS will offer more comprehensive sample 
characterization on-line for more robust results. A multi-scale modeling effort will allow extracting more 
information from muscle X-ray diffraction studies. The proposed developments in multi-scale simulations for 
interpreting single molecule SAXS data will profoundly benefit studies of multicomponent systems that show 
considerable conformational heterogeneity. Our relationship with the CCP-SAS project will enable us to widely 
disseminate the advanced modeling tools we create to not only all our DBP's, collaborative and service users 
but to the wider biomedical community. Our Driving Biomedical Projects, collaborative, and service projects 
have relevance to basic mechanisms of muscle function, heart disease, retinitis pigmentosa, cancer and 
neuro-degenerative diseases. Our proposed training activities are designed to ensure safe, efficient and 
productive use of the resource by our users. Our proposed dissemination activities are designed to grow our 
user community by keeping targeted biomedical communities well-informed of resource capabilities.

## Key facts

- **NIH application ID:** 9841406
- **Project number:** 5P41GM103622-24
- **Recipient organization:** ILLINOIS INSTITUTE OF TECHNOLOGY
- **Principal Investigator:** THOMAS C IRVING
- **Activity code:** P41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $25,293
- **Award type:** 5
- **Project period:** — → 2021-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9841406

## Citation

> US National Institutes of Health, RePORTER application 9841406, Core 1 Training pp.332-366 (5P41GM103622-24). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9841406. Licensed CC0.

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