# Improving Accessibility and Personalization of Cognitive Remediation for Schizophrenia

> **NIH NIH P50** · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · 2020 · $197,176

## Abstract

PROJECT SUMMARY – PROJECT 1
 Consistent with the aims of the OPAL center, this project will explore adaptations of treatments for
schizophrenia, with the goal of optimizing their effectiveness in real-world clinical settings and readiness for
broad deployment. Schizophrenia is associated with cognitive deficits that negatively impact essential areas of
daily functioning. NY State Office of Mental Health (OMH) is the first and largest state system of care to
implement a statewide program of cognitive remediation (CR), an evidence-based practice for improving
cognition and aiding functional recovery. Through Cognitive Remediation to Promote Recovery (CR2PR), CR
is now offered in outpatient programs, with plans to expand to more services and further adapt implementation
to improve treatment outcomes. This project will work directly with OMH clinics and clinicians, and draw on the
resources of the Center's trans-disciplinary expertise to build upon and improve current CR delivery methods.
 This project will study the impact of two adaptations. One adaptation focuses on increasing the
accessibility of the program, which participants report is limited by the requirement of twice weekly attendance.
This project will therefore compare the feasibility and acceptability of delivering CR in either two clinic-based
sessions (Clinic) or one clinic and one remote session (Hybrid) per week. Semi-structured qualitative
interviews will be conducted with stakeholders to explore the impact of the adaptation. The second adaptation
is intended to improve personalization of CR by systematically accounting for individual differences in
neurocognitive needs. Drawing upon convergent evidence for tailoring CR based on need for early auditory
processing (EAP) training, this project examines whether integrating a measure of EAP into the current
baseline assessment facilitates personalization of the menu of restorative computer-based exercises used in
CR. The team's expertise in CR implementation and dissemination, clinical trials, and integrative quantitative
and qualitative methods altogether support the aims of this project. Feasibility parameters and
qualitative/quantitative data analyses of facilitators and barriers to Hybrid CR delivery will together inform
further treatment refinement and the design of a larger effectiveness trial of Clinic versus Hybrid CR. We will
study how EAP assessment is employed by practitioners to personalize the CR treatment plan and examine if
EAP improvement is associated with cognitive outcomes in public practice CR settings. Finally we will compare
cognitive, functional, and service use outcomes in Hybrid versus Clinic CR and use exploratory methods to test
whether subgroups of patients benefit more from Hybrid or Clinic delivery approaches. This project supports
the mission of the Center, to rapidly translate laboratory evidence to clinical practice in a manner congruent
with the realities of publically funded clinics. By improving CR ut...

## Key facts

- **NIH application ID:** 9841454
- **Project number:** 5P50MH115843-03
- **Recipient organization:** NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
- **Principal Investigator:** Alice Medalia
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $197,176
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9841454

## Citation

> US National Institutes of Health, RePORTER application 9841454, Improving Accessibility and Personalization of Cognitive Remediation for Schizophrenia (5P50MH115843-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9841454. Licensed CC0.

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