# Strategies and Methods for Complex Molecule Synthesis

> **NIH NIH R35** · UNIVERSITY OF CALIFORNIA BERKELEY · 2020 · $599,528

## Abstract

Project Summary/Abstract
The goal of this program is to develop new strategies and methods for the synthesis of
biologically active secondary metabolites (natural products). A significant portion of our
efforts will be dedicated to identifying efficient preparations of these complex molecules.
These compounds and their unique derivatives will serve as novel small molecules to
combat a range of indications associated with cancer as well as inflammation and pain.
Our synthetic studies will lead to new applications of C–C bond activation methodology
in organic synthesis as well as a Network Analysis approach to the preparation of
topologically complex molecules. Our work will also highlight new directions for the use
of carvone as a sustainable starting material for synthesis. Finally, working with
collaborators, we will gain unique entry into the use of natural products and their
derivatives to perturb biological function and ultimately provide promising starting points
for new therapeutics.

## Key facts

- **NIH application ID:** 9841949
- **Project number:** 5R35GM130345-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA BERKELEY
- **Principal Investigator:** Richmond Sarpong
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $599,528
- **Award type:** 5
- **Project period:** 2019-01-01 → 2023-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9841949

## Citation

> US National Institutes of Health, RePORTER application 9841949, Strategies and Methods for Complex Molecule Synthesis (5R35GM130345-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9841949. Licensed CC0.

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