# Insights into the Molecular and Cellular Mechanisms governing Endothelial Function

> **NIH NIH R35** · YALE UNIVERSITY · 2020 · $1,077,806

## Abstract

Project Summary
To date, endothelial dysfunction is defined by a constellation of phenotypes including up-regulation of
pro-inflammatory pathways, enhanced thrombogenicity, increased reactive oxygen species and
reduced NO synthesis/bioavailability1, 2. Our lab has focused on the latter pathway by understanding
how endothelial nitric oxide synthase (eNOS), the exclusive source of endothelial derived NO as a
relaxing factor for smooth muscle, is regulated and these studies have led to the discovery of additional
pathways that regulate several aspects of endothelial cell biology and function3. Thus, the central goal
for this grant is to integrate advances derived from our previous work on eNOS to explore a broader
range of pathways that can improve endothelial and vascular health.

## Key facts

- **NIH application ID:** 9841982
- **Project number:** 5R35HL139945-03
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** William C Sessa
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,077,806
- **Award type:** 5
- **Project period:** 2018-01-01 → 2024-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9841982

## Citation

> US National Institutes of Health, RePORTER application 9841982, Insights into the Molecular and Cellular Mechanisms governing Endothelial Function (5R35HL139945-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9841982. Licensed CC0.

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