# Baylor/Texas Children's Hospital Pediatric Heart Network

> **NIH NIH UG1** · BAYLOR COLLEGE OF MEDICINE · 2020 · $348,697

## Abstract

Abstract
Congenital and acquired heart disease is a significant health problem in children worldwide and is responsible
for considerable acute illness and disability throughout childhood. Research is needed to improve the
outcomes and quality of life for children living with congenital and acquired heart disease. Single research
centers acting alone encounter difficulties with conducting adequately powered clinical research studies due to
small patient populations. Well-designed multicenter clinical research studies are needed. The purpose of this
grant application is for Baylor College of Medicine (BCM)/Texas Children's Hospital (TCH) Heart Center to
renew participation as a Clinical Research Center of the Pediatric Heart Network (PHN) sponsored by National
Heart, Lung, and Blood Institute. The goal of the PHN is to evaluate therapeutic and management strategies
for children and adults with congenital heart defects and for children with inflammatory heart disease, heart
muscle disease, and arrhythmias through multicenter clinical research. BCM/TCH will support the goals of the
PHN by pursuing the following specific aims: SA1) To work cooperatively within the PHN to provide scientific
expertise and supervision in development of studies related to pediatric cardiovascular disease and adult
congenital heart disease, to conduct such studies and disseminate results over the 7-year cycle; SA2) To
utilize the robust and complex TCH patient population available for potential study enrollment in order to
identify, enroll and retain participants in all multi-center cardiovascular clinical trials; SA3) To effectively and
efficiently manage and communicate all necessary resources for optimal conduct and performance in order to
support PHN studies as well as activities, both research and administrative; and SA4) To utilize BCM/TCH's
unique and robust data integration capabilities to interface with a variety of cardiovascular databases and
registries, both internal and external, in order to leverage and contribute to clinical research activities
throughout the PHN. Baylor/TCH Heart Center has experienced multidisciplinary leadership in Cardiology,
Cardiac Surgery, Cardiac Critical Care, and Cardiovascular Anesthesiology with a successful 5-year track
record of participation as a PHN clinical research center. TCH has a large patient population having provided
over 3.5 million patient encounters in FY2015. TCH is located in a diverse and fast-growing region with the
U.S., which provides a diverse patient population. This is reflected in the Heart Center's diverse diagnoses
undergoing over 913 cardiac operating room cases, 1,150 cardiac catheterizations, 27,746 echocardiograms,
and currently following more than 900 patients (0 to +18 years) with single ventricle anatomy. With this clinical
presence and capabilities in conjunction with a proven track record in participating in clinical research
Baylor/TCH Heart Center proposes to continue to be a leading Clinical...

## Key facts

- **NIH application ID:** 9842322
- **Project number:** 5UG1HL135666-04
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **Principal Investigator:** Jeffrey Stephen Heinle
- **Activity code:** UG1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $348,697
- **Award type:** 5
- **Project period:** 2017-01-01 → 2023-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9842322

## Citation

> US National Institutes of Health, RePORTER application 9842322, Baylor/Texas Children's Hospital Pediatric Heart Network (5UG1HL135666-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9842322. Licensed CC0.

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