# Regulation of a virulence switch in Acinetobacter baumannii

> **NIH NIH R21** · EMORY UNIVERSITY · 2020 · $158,377

## Abstract

The Gram-negative bacterium Acinetobacter baumannii is a leading cause of
nosocomial infections in humans. The emergence of A. baumannii strains resistant to
most, and in some cases, all available antibiotics has made the treatment of these
infections exceedingly difficult. This underlies the importance of finding new ways to
combat these infections. This proposal addresses regulation of a high-frequency
phenotypic switch in A. baumannii that controls virulence. The goals of this proposal are
to understand regulatory mechanism responsible for this switch and
identify/characterize a quorum sensing signal that stimulates this switch.

## Key facts

- **NIH application ID:** 9842390
- **Project number:** 5R21AI142489-02
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Philip N. Rather
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $158,377
- **Award type:** 5
- **Project period:** 2019-01-01 → 2021-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9842390

## Citation

> US National Institutes of Health, RePORTER application 9842390, Regulation of a virulence switch in Acinetobacter baumannii (5R21AI142489-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9842390. Licensed CC0.

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