# Fibrinolysis Evaluation in A-TREAT (‘FEAT’ Study)

> **NIH NIH R01** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $391,250

## Abstract

ABSTRACT
This ancillary study will recruit subjects as they are simultaneously enrolled into the ongoing
randomized placebo-controlled study, The American Trial using Tranexamic Acid in Thrombocytopenia
(`A-TREAT'; NCT02578901). The goals of the parent A-TREAT study are to evaluate whether the
antifibrinolytic agent tranexamic acid improves the hemostatic efficacy of prophylactic platelet
transfusion, and reduces the use of platelet and red cell transfusions with an acceptable safety profile in
patients with severe hypoproliferative thrombocytopenia following chemotherapy or stem cell
transplantation. Plasma samples obtained from study subjects will be used to determine whether a
`hyperfibrinolytic' plasma profile can be identified using novel global assays of fibrinolysis, and whether
this profile is associated with higher bleeding rates. The results of this study will not only address
mechanisms of bleeding (in addition to thrombocytopenia) in severely thrombocytopenic patients, but
will also suggest a potential biomarker of bleeding risk and/or the benefit of tranexamic acid in
individual patients undergoing myeloablative therapy. Furthermore, given the intense recent interest in
the role of tranexamic acid in a variety of other inherited and acquired bleeding disorders, we anticipate
that these studies will also be highly relevant to a greater understanding of pathophysiological
mechanisms and/or the development of a useful biomarker in other clinical scenarios.

## Key facts

- **NIH application ID:** 9842979
- **Project number:** 5R01HL146226-02
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** Nigel S. Key
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $391,250
- **Award type:** 5
- **Project period:** 2019-01-01 → 2021-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9842979

## Citation

> US National Institutes of Health, RePORTER application 9842979, Fibrinolysis Evaluation in A-TREAT (‘FEAT’ Study) (5R01HL146226-02). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9842979. Licensed CC0.

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