# Multimodal Gating Mechanisms of TRPV1 Ion Channels

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 2020 · $419,850

## Abstract

Project summary
The goal of this proposal is to determine the molecular mechanisms underlying multi-modal gating of
the pain-receptor ion channel TRPV1 by interrogating the structural mechanisms for activation by
capsaicin, heat, protons, savory compounds, and signaling lipids. We will use tmFRET and
computational methods to determine the conformational change induced by each modality and the
coupling between modalities.

## Key facts

- **NIH application ID:** 9843458
- **Project number:** 5R01GM125351-03
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Sharona E Gordon
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $419,850
- **Award type:** 5
- **Project period:** 2018-01-01 → 2021-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9843458

## Citation

> US National Institutes of Health, RePORTER application 9843458, Multimodal Gating Mechanisms of TRPV1 Ion Channels (5R01GM125351-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9843458. Licensed CC0.

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