# Leukemia Tissue Bank Shared Resource

> **NIH NIH P30** · OHIO STATE UNIVERSITY · 2020 · $60,883

## Abstract

CORE-005: LEUKEMIA TISSUE BANK SHARED RESOURCE (LTB)
PROJECT SUMMARY / ABSTRACT
The OSUCCC Leukemia Tissue Bank (LTB) is a critical resource for OSUCCC investigators, and the Leukemia
Research Program, conducting translational research in hematologic malignancies. The LTB procures samples
in 2 ways, via a general biobanking protocol as well as using specific clinical research protocols, collecting
blood, bone marrow, leukapheresis products and others as requested. The LTB performs rapid processing of
biospecimens, e.g., cell isolation and cryopreservation, assesses the quality of collected samples, delivers
fresh samples or stores them for future use, provides clinical annotation for study subjects and distributes
samples to investigators. Additional services available to researchers include serial collections, specialized
processing, specialized specimen preparation and characterization, protocol optimization, and assistance with
design of laboratory and clinical correlative studies. The LTB is a longstanding biobank, and with a >90%
subject participation rate, it has collected 14,233 samples from 5,195 subjects, allowing for detailed
investigations of many subtypes of hematologic cancers. Dr. Lucas is the Director of the LTB, and Dr.
Bloomfield is the Senior Faculty Advisor. The Specific Aims of the LTB are: 1) to consent subjects and
procure samples from hematologic malignancy patients using state-of-the art procedures to optimally preserve
the value of patient materials; 2) to uniformly process, characterize and store biospecimens; and, 3) to provide
biospecimens with associated clinical, pathological and genomic data to OSUCCC researchers and to outside
institutions so that they can correlate findings from patient samples with clinical or population-based outcomes.
The LTB coordinates with other OSUCCC shared resources, e.g., Analytical Cytometry, Genomics,
Pharmacoanalytical, and the Clinical Trials Processing Laboratory. During the last five year grant period, the
LTB supported the research of 34 investigators, 30 of whom were OSUCCC members. Together, the LTB
samples were used for 98 publications, of which 18 were published in journals with an impact factor >10, and
15 NCI grants. As a future direction, the facility will be expanded with OSUCCC support as required to meet
researchers' needs. Working with the Genomics Shared Resource and the Bioinformatics Shared Resource,
we will embark upon indexing leukemia samples based on genomic profiles. The LTB leverages extensive
institutional support and seeks only 15.3% support from CCSG funds. The Leukemia Tissue Bank Shared
Resource is part of the Clinical Grouping.

## Key facts

- **NIH application ID:** 9843863
- **Project number:** 5P30CA016058-44
- **Recipient organization:** OHIO STATE UNIVERSITY
- **Principal Investigator:** David Matthew Lucas
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $60,883
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9843863

## Citation

> US National Institutes of Health, RePORTER application 9843863, Leukemia Tissue Bank Shared Resource (5P30CA016058-44). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9843863. Licensed CC0.

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