# Medicinal Chemistry Shared Resource

> **NIH NIH P30** · OHIO STATE UNIVERSITY · 2020 · $64,121

## Abstract

CORE-010: MEDICINAL CHEMISTRY SHARED RESOURCE (MCSR)
PROJECT SUMMARY / ABSTRACT
The Medicinal Chemistry Shared Resource (MCSR) is critical to the OSUCCC drug development mission
supporting preclinical studies leading to more rationale clinical trial designs and effective cancer therapies.
Established during the last grant application as a developing shared resource, the MCSR is now being
proposed as a formal shared resource. The MCSR's Senior Faculty Advisor is Dr. Ching-Shih Chen, a highly
accomplished medicinal chemist, who established the MCSR as the director. The director of the MCSR is now
Dr. Chad Bennett, a recent recruit, who is an experienced medicinal and process chemist with industry
experience. The MCSR has three Specific Aims: 1) to custom-synthesize new agents to improve cancer
therapeutics; 2) to synthesize agents for cancer researchers needing compounds that are not available; and, 3)
lead optimization by conducting structure-activity relationship (SAR) analyses and structure-based design. To
accomplish these aims, the MCSR integrates the expertise of multiple disciplines, including medicinal
chemistry, process chemistry, computational chemistry, structural biology and molecular pharmacology. The
MCSR is located in the 4th floor of Biomedical Research Tower, in close proximity to most OSUCCC
investigators. Since 2011, when the MCSR was established, the MCSR has provided chemical synthesis
services to 32 OSUCCC investigators, 9 investigators from other NCI-sponsored institutions, and has
synthesized 33 compounds that were otherwise not available from commercial sources or were cost
prohibitive. These agents have helped investigators to conduct proof-of-concept in vitro and/or in vivo
preclinical experiments that have aided in a better understanding of cancer biology and led to rationale clinical
trial development. The MCSR has contributed to 63 publications over the last grant period, 6 of which were in
journals with an impact factor >10, and it has supported 6 NCI grants (not including services provided for 9
other NCI Cancer Centers). The future plans are to build a formal partnership with the OSUCCC's Drug
Development Institute and to increase services for lead optimization. The MCSR leverages extensive
institutional support, and seeks only 15.4% support from CCSG funds. The Medicinal Chemistry Shared
Resource is part of the Analytics Grouping.

## Key facts

- **NIH application ID:** 9843869
- **Project number:** 5P30CA016058-44
- **Recipient organization:** OHIO STATE UNIVERSITY
- **Principal Investigator:** CHAD E BENNETT
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $64,121
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9843869

## Citation

> US National Institutes of Health, RePORTER application 9843869, Medicinal Chemistry Shared Resource (5P30CA016058-44). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9843869. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*