# Comparative Pathology and Mouse Phenotyping Shared Resource

> **NIH NIH P30** · OHIO STATE UNIVERSITY · 2020 · $87,285

## Abstract

CORE-014: COMPARATIVE PATHOLOGY AND MOUSE PHENOTYPING (CPMPSR)
PROJECT SUMMARY / ABSTRACT
The Comparative Pathology and Mouse Phenotyping Shared Resource (CPMPSR) provides expert, readily
available and affordable pathology support to investigators utilizing animal models to study human cancer.
The use of animal models in cancer research, particularly inbred and genetically engineered mice, has
increased exponentially over the past several years due to technological advances and completion of the
sequencing of the human and mouse genomes. Virtually every OSUCCC member utilizing experimental animal
models will need at least some of the services provided by the CPMPSR. The Specific Aims of the CPMPSR
are: 1) to provide support for preclinical efficacy and toxicity studies utilizing a variety of animal species; 2) to
provide consultative services to OSUCCC investigators for optimal experimental design, sample submission
and data analysis, recommendations as needed for various ancillary tests, referrals to other OSUCCC shared
resources and cores, and referrals to investigators' laboratories with specific expertise (e.g., more specialized
clinical pathology testing, electron microscopy, imaging, behavioral and physiological testing); and, 3) to
provide consultations to investigators at the time of grant applications and manuscript submissions by
providing details about methods and pathologic findings. The services provided by CPMPSR, directed by Dr.
Krista La Perle include macroscopic and microscopic tissue evaluations, clinical pathology testing,
comprehensive histology and immunohistochemistry, microscopic slide imaging and quantitative analysis. The
CPMPSR also provides comprehensive phenotypic characterization of genetically-engineered mice, including
detailed characterization of embryos. Radiography is performed by the CPMPSR to enhance morphologic
evaluations on post-mortem specimens. The CPMPSR regularly interacts with other OSUCCC shared
resources such as the Microscopy Shared Resource and Biomedical Informatics Shared Resource. Over the
past grant period, the CPMPSR was utilized by all five OSUCCC Research Programs studying carcinogenesis
and using preclinical models for drug development. CPMPSR provided services to 117 OSUCCC members,
and these members accounted for 53% of usage. The CPMPSR has also supported the research for 93 cancer
publications, of which 11 were published in journals with an impact factor >10. The CPMPSR supported 9
programmatic grants (e.g., P01s and SPOREs). The future plans of the CPMPSR are to add capacity through
the hiring of an additional pathologist, providing additional immunohistochemistry services and upgrading
existing software. The CPMPSR leverages extensive institutional support, and seeks only 6.5% support from
CCSG funds. The Comparative Pathology and Mouse Phenotyping Shared Resource is part of the
Diagnostics Grouping.

## Key facts

- **NIH application ID:** 9843873
- **Project number:** 5P30CA016058-44
- **Recipient organization:** OHIO STATE UNIVERSITY
- **Principal Investigator:** KRISTA MARIE DUBRAY LA PERLE
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $87,285
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9843873

## Citation

> US National Institutes of Health, RePORTER application 9843873, Comparative Pathology and Mouse Phenotyping Shared Resource (5P30CA016058-44). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/9843873. Licensed CC0.

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