# MHC Genetic Typing Core

> **NIH NIH U42** · TEXAS BIOMEDICAL RESEARCH INSTITUTE · 2020 · $198,309

## Abstract

PROJECT SUMMARY – Core 3: MHC Genetic Typing Core
The objectives of the MHC and Genetic Typing Core are to support the genetic characterization and breeding
strategy of the SPF Colony, with a focus towards optimizing the colony for AIDS-related research. The Core's
three aims build upon the current strengths of the Core and incorporate new approaches towards more
rigorous genetic characterization of the colony.
In Aim 1, MHC Class I alleles, important to AIDS investigators, will be genotyped using high resolution
 sequencing in collaboration with Dr. Wiseman at the Wisconsin NPRC. The genotypes on 185
 animals will be obtained each year.
In Aim 2, both genotype-by-sequencing (GbS) and whole genome sequencing (WGS) will be used to provide
 a) a more robust Ancestry Informative Markers (AIMs) set defining Indian and Chinese ancestry
 information both genome-wide and at specific loci, b) parentage information to verify pedigrees and
 investigate colony origins, c) genotypic information to allow for the identification of animals carrying
 known and potentially new alleles relevant for AIDS-related research and impacting infectious disease
 pathogenesis and vaccine effectiveness, and d) development of a means to share the genetic data
 with the research community using a web-based user interface allowing access to LabKey-managed
data.
In Aim 3, genetic data from Aims 1 and 2 will be used to maximize genetic diversity of the colony, while
 maintaining sufficient numbers of animals with specific MHC Class I alleles and ancestry for SIV/HIV
 related studies. Core 3 will work with Core 1 and the SPF Oversight Committee to assemble breeding
 groups using animals derived from the both Colonies 1 and 2.

## Key facts

- **NIH application ID:** 9844009
- **Project number:** 5U42OD010442-19
- **Recipient organization:** TEXAS BIOMEDICAL RESEARCH INSTITUTE
- **Principal Investigator:** SHELLEY A COLE
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $198,309
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9844009

## Citation

> US National Institutes of Health, RePORTER application 9844009, MHC Genetic Typing Core (5U42OD010442-19). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9844009. Licensed CC0.

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