# Interactions Between Host Genetics and the Gut Microbiome in CNS Autoimmunity

> **NIH NIH R01** · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · 2020 · $341,250

## Abstract

Project Summary
 Multiple sclerosis (MS) is a devastating autoimmune neuroinflammatory disease with a strikingly increasing
incidence world-wide, implicating the influence of environmental factors. While genetics of MS are beginning to
be understood, they can account for at most ~30% of the disease risk. The remainder of the disease risk is
accounted for by environmental factors and gene-by-environment (G×E) interactions. Mechanisms of G×E in
MS are not well understood, and are difficult to study in humans. Mounting evidence implicates a novel
environmental risk factor for MS: dysregulation of the gut microbiome. In this application, we propose to take a
genome-wide approach to identify gene × microbiome interactions in a novel and powerful mouse genetics
system. These studies cannot be carried out in humans, and they will provide important mechanistic
understanding of G×E in autoimmune disease of the CNS, and deliver cause vs. effect distinctions that are
lacking in epidemiologic studies.

## Key facts

- **NIH application ID:** 9844988
- **Project number:** 5R01NS097596-04
- **Recipient organization:** UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
- **Principal Investigator:** Dimitry N Krementsov
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $341,250
- **Award type:** 5
- **Project period:** 2017-03-15 → 2022-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9844988

## Citation

> US National Institutes of Health, RePORTER application 9844988, Interactions Between Host Genetics and the Gut Microbiome in CNS Autoimmunity (5R01NS097596-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9844988. Licensed CC0.

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