# High-Definition Conformal Electronics for VT/VF

> **NIH NIH R01** · GEORGE WASHINGTON UNIVERSITY · 2020 · $610,590

## Abstract

Project Summary/Abstract
Ventricular arrhythmias including ventricular tachycardia (VT) and ventricular fibrillation (VF) are responsible
for 300,000 sudden cardiac deaths a year in the US. Electrotherapy has been effective in arresting VT/VF but
the high-energy biphasic shocks can lead to myocardial damage and associated co-morbidities. Moreover the
implantable cardioverter defibrillator technology (ICD) has low VT/VF sensing resolution, which can lead to
inappropriate shocks and associated psychological distress, resulting in diminished quality of life or even
death. Thus, there is an unmet need for high-definition VT/VF sensing to reduce inappropriate shocks and
similarly, an unmet need for high-definition ultra-low energy electrotherapy to terminate VT/VF. In this
project, we present a novel approach to VT/VF sensing and electrotherapy and redesign the ICD into
cardiovascular implantable electronic device (CIED). We will employ two break-through technological
platforms to implement our novel method: (1) A novel conformal chiplet electronics real-time networks
(CCERN) technology developed by Co-Investigator Dr. Rogers and an (2) innovative panoramic,
transillumination optical mapping developed by PI Dr. Efimov. We will conduct high-definition, panoramic,
transillumination, optical mapping in conjunction with high-definition CCERN to (1) characterize the
transmural VT/VF dynamics, (2) determine the optimal number of sensors needed to dynamically track the
excitable gaps, phase singularities, and wavefronts during VT/VF, and (3) terminate VT/VF using optimal
definition ultra low-energy high-definition electrotherapy. This proposed work would advance our
understanding of VT/VF and pave the path towards creating a targeted individualized therapy dynamically
tailored for each arrhythmia episode for each patient.

## Key facts

- **NIH application ID:** 9845787
- **Project number:** 5R01HL141470-02
- **Recipient organization:** GEORGE WASHINGTON UNIVERSITY
- **Principal Investigator:** IGOR R EFIMOV
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $610,590
- **Award type:** 5
- **Project period:** 2019-01-10 → 2022-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9845787

## Citation

> US National Institutes of Health, RePORTER application 9845787, High-Definition Conformal Electronics for VT/VF (5R01HL141470-02). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9845787. Licensed CC0.

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