# Crystallography and Computational Biosciences Shared Resource

> **NIH NIH P30** · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2020 · $51,560

## Abstract

CRYSTALLOGRAPHY AND COMPUTATIONAL BIOSCIENCES SHARED RESOURCE 
Project Summary 
The Crystallography and Computational Biosciences Shared Resource (CCBSR) is a highly-specialized 
Resource that provides Wake Forest Baptist Comprehensive Cancer Center (WFBCCC) members with access 
to expertise, consultation, and state-of-the-art structural and computational biology approaches. The resulting 
data enhance ongoing, peer-reviewed projects and new funding applications. The CCBSR's scientific 
importance centers on the need to understand the structural basis for protein-protein, protein-DNA/RNA, and 
protein-ligand/drug interactions; and how dynamics affect these interactions. The use of the CCBSR has 
steadily increased, as have the depth and breadth of projects. From 2011−2015, the Co-Directors have worked 
with 27 laboratories from 11 departments (74% WFBCCC members; all with peer-reviewed funding) to publish 
36 manuscripts, solve 9 new structures, perform experiments for 18 existing and newly-funded grants, and 
collect preliminary data for new funding applications. The CCBSR has three co-Directors (W. Todd Lowther, 
Ph.D.; Thomas Hollis, Ph.D.; Fred Salsbury, Ph.D.), each with different areas of scientific, experimental, and 
computational expertise. Therefore, after initial consultation, one or more of the Co-Directors assists the 
WFBCCC member with the development of their project, matching the project to the expertise of a specific Co- 
Director. The Specific Aims of the CCBSR are to: 1) Determine the appropriate crystallography and/or 
computational approach for structural analysis of important biomolecules in cancer research; 2) Conduct initial 
crystallization trials or simulations to generate preliminary data for grant applications; and 3) Provide facilities 
and expertise for funded projects to determine the structure of important biomolecules in cancer research. The 
crystallography component is managed by the WFBCCC but also has institutional funding. The Co-Directors 
attend the quarterly WFBCCC Shared Resources meeting, which includes discussions on activity, best 
practices, enhanced capabilities, and administrative management techniques. These meetings provide an 
overview of operations, finances, and utilization, and facilitate regular evaluation by WFBCCC leadership.

## Key facts

- **NIH application ID:** 9848533
- **Project number:** 5P30CA012197-45
- **Recipient organization:** WAKE FOREST UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** W TODD LOWTHER
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $51,560
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9848533

## Citation

> US National Institutes of Health, RePORTER application 9848533, Crystallography and Computational Biosciences Shared Resource (5P30CA012197-45). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9848533. Licensed CC0.

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