# Biostatistics Shared Resource

> **NIH NIH P30** · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2020 · $183,372

## Abstract

The primary goal of the Biostatistics and Bioinformatics Shared Resource (BBSR) is to facilitate the peer-reviewed
research of Wake Forest Baptist Comprehensive Cancer Center (WFBCCC) members. The BBSR
collaborates with members from all four scientific Programs throughout all phases of cancer-related research
projects. Major responsibilities are assumed for methodological, statistical, bioinformatics, and computational
issues, including study design, sampling, statistical aspects of clinical trial monitoring, interim reviews, and final
analysis. The BBSR supports the following five areas: 1) Clinical Protocol Development, including development
of appropriate statistical designs, preparing statistical sections, and reviewing the statistical content of all
protocols submitted for review at the WFBCCC; 2) Clinical Protocol Monitoring and Analyses, including
monitoring patient accrual, providing support for quality assurance efforts, and performing interim (when
needed) and final analyses; 3) Statistical Design and Data Analysis in Support of Grant Development and
Publications, which includes collaborations with WFBCCC investigators from all Programs to provide guidance
and support in all stages of research studies and grants. This aspect of service involves meeting with
WFBCCC investigators to discuss the design and analysis plans for potential grants, conducting regular
planning sessions with WFBCCC investigators about potential grants, performing statistical analyses of data
and providing interpretations of results as parts of presentations, abstracts, and publications; 4) Informatics
Services to WFBCCC investigators from all Programs, including genomics data processing, bioinformatics
analyses, data annotation and visualization/sharing to support basic, translational and clinical cancer research
by leveraging the institutionally-maintained Translational Data Warehouse; and 5) Leadership, Education, and
Training, including participation in graduate-level courses, T32 training grants, mentoring teams for K
awardees and other young investigators, membership/leadership on committees responsible for scientific and
administrative decisions for the WFBCCC, and coordination of a monthly seminar series and short courses on
statistical and/or bioinformatics methods for WFBCCC members.
The BBSR is co-directed by Ralph D’Agostino, Jr., Ph.D., and Xiaobo Zhou, Ph.D., and is a highly utilized and
cost-efficient Resource for the WFBCCC. From November 1, 2014 through October 31, 2015, the BBSR
provided over 5,000 hours of support for cancer-related work and assisted 105 investigators (90 WFBCCC
Members) from all four WFBCCC Programs while receiving approximately 1.9 FTEs of financial support from
the Cancer Center Support Grant (with additional support provided by WFBCCC institutional dollars). In
addition, during the reporting year the BBSR provided statistical support to 23 newly-opened investigator
initiated protocols, provided support for 20 clinical protoco...

## Key facts

- **NIH application ID:** 9848545
- **Project number:** 5P30CA012197-45
- **Recipient organization:** WAKE FOREST UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Ralph B. DAgostino
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $183,372
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9848545

## Citation

> US National Institutes of Health, RePORTER application 9848545, Biostatistics Shared Resource (5P30CA012197-45). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9848545. Licensed CC0.

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