# Human Genetics and Microbiome Core

> **NIH NIH P30** · MASSACHUSETTS GENERAL HOSPITAL · 2020 · $130,364

## Abstract

HUMAN GENETICS AND MICROBIOME CORE: PROJECT SUMMARY
The Human Genetics and Microbiome Core will be co-directed by Mark Daly and Curtis Huttenhower. The
services offered within this core are composed of a suite of services from more routine and heavily used
molecular biology services (e.g., whole plasmid DNA sequencing) to computationally complex tools to analyze
the role of genetics and the microbiome in IBD (e.g., statistical association testing between host genotypes and
microbiome).Central to all services are formal and informal end-to-end consultations and training on
experimental design, data generation, and bioinformatics analysis. A team of bioinformaticists and software
developers with in-depth expertise are available within the Core to provide collaborative capacity for analysis of
genetics, microbiome, and/or functional data
This core will be a major connection point for clinicians and basic researchers, as it operates at the intersection
between patient samples and basic research techniques. The specific aims of Human Genetics and
Microbiome Core are divided according to its two themes. For genetics, the Core will (1) facilitate the
application of advanced experimental platforms for genetics, genomics, and high-throughput data analysis to
discovery efforts relevant to IBD; (2) provide a centralized facility and personnel for performing state-of-the-art
recombinant and PCR-based DNA procedures and RNA interference and provide cost-effective and high-
quality molecular biology reagents and services; and (3) provide a resource for disseminating a wide range of
molecular biology, genetic, and bioinformatics technologies. For microbiome services, the Core will (1)
provide an end-to-end sampling and multi’omic profiling system for the host and microbiota in IBD and
gastrointestinal disease; (2) provide computational resources to analyze and interpret the microbiome; and (3)
develop cutting-edge solutions in microbiome research that will drive therapeutic discovery.

## Key facts

- **NIH application ID:** 9848611
- **Project number:** 5P30DK043351-30
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Mark Joseph Daly
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $130,364
- **Award type:** 5
- **Project period:** — → 2021-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9848611

## Citation

> US National Institutes of Health, RePORTER application 9848611, Human Genetics and Microbiome Core (5P30DK043351-30). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9848611. Licensed CC0.

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