# Clinical Core

> **NIH NIH P30** · MASSACHUSETTS GENERAL HOSPITAL · 2020 · $97,363

## Abstract

CLINICAL CORE: PROJECT SUMMARY
The Clinical Core will be led by Ramnik Xavier (Director), Andrew Chan (Co-Director), and Ashwin
Ananthakrishnan (Technical Director). The services offered by the Clinical Core can be organized into (1)
consultation, training, and education; (2) biospecimen services; and (3) data collection and analysis services.
Consultation and education take the form of consulting in research methods and analysis, as well as education
and training of junior investigators, residents, and fellows. Biospecimen services include clinical database and
patient identification, biospecimen collection and processing services, tissue biorepository services, and serum
biobank services. Data collection and analysis is facilitated through regulatory services, a genotype and
microbiome library, and bioinformatics support.
This core serves as a hub for interactions between clinicians and basic researchers, allowing basic scientists to
test hypotheses in human samples and clinicians to gain valuable insight into disease states. The specific
aims of the Clinical Core are to (1) build a biorepository of patients with Crohn’s disease and ulcerative colitis
with accurate phenotyping of disease as well as sampling of blood, stool, urine, and tissue in various disease
states (active/inactive disease) and related to various therapeutic and environmental perturbations; (2) define
the phenotypic implications of genetic loci with regard to clinical manifestations, response to therapy, and to
examine the interaction with the environment; (3) facilitate education and training in research by providing
consultations regarding study design, methods, and analysis as well as attract new investigators to the field
through these services; and (4) translate laboratory and clinical research findings into interventions that serve
to improve diagnosis, develop biomarkers for disease monitoring and prognostication, and optimize treatment
algorithms.

## Key facts

- **NIH application ID:** 9848616
- **Project number:** 5P30DK043351-30
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Ramnik J Xavier
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $97,363
- **Award type:** 5
- **Project period:** — → 2021-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9848616

## Citation

> US National Institutes of Health, RePORTER application 9848616, Clinical Core (5P30DK043351-30). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9848616. Licensed CC0.

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