# Developmental Funds

> **NIH NIH P30** · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2020 · $312,835

## Abstract

Developmental Funds
ABSTRACT
The City of Hope Comprehensive Cancer Center requests CCSG developmental funds to support pilot research
projects and developing an additional new shared resources to strengthen research initiatives and promote
basic, translational and clinical science research activities. Funding pilot projects and developing shared
resources will collectively enhance the ability of the COHCCC to serve the catchment area and mitigate the
impact of cancer in the region. COHCCC believes that these activities will enable the Cancer Center to provide
the optimal environment to focus the power of precision medicine, basic science inquiry, drug discovery and
development, and behavioral interventions to decrease cancer incidence, morbidity, and mortality.
The plan for the next funding cycle is to develop a new Multi-Scale Translational Research Core. Multi-scale
modeling uses computational analysis to integrate linked measurements made at different scales of
measurement (populations, individuals, microenvironment, cells, DNA/RNA/protein, and analytes). Over the past
3 years, the scope City of Hope Comprehensive Cancer Center (COHCCC) Cancer Control and Population
Science (CCPS) research has expanded beyond classic epidemiologic testing of associations in large cohorts
to biology-focused, translational multi-disciplinary studies that integrate multi-scale data from cohorts with
mechanistic mouse-human co-studies, omics (genetics, genomics, proteomics), and analytes (drug levels,
endocrine disruptors, carcinogens). The Multi-Scale Translational Research (MSTR) Core in development aims
to provide services that facilitate and enhance NCI funded multi-scale research at each level of scale (zip code,
individuals, microenvironment, cells, DNA/RNA/protein, and analytes). Multi-scale modeling requires integration
of large data sets; to this end, the Core will provide services in data curation, annotation, validation, and
assessment of rigor.
To support NIH funded COHCCC multi-scale projects, the MSTR Core in development will 1) offer unique
services and 2) collaborate and integrate with COHCCC Cores and Caltech, ORIONTM, and TGenTM partners.
Unique services offered by the MSTR Core in development include 1) expertise in multi-scale modeling, 2)
curation, annotation, and validation of the rigor, reproducibility, and accuracy of tissue, omic, and analyte data,
3) genetic admixture assessment, 4) navigation of existing COH analyte services, 4) expertise in custom tissue
engineering and microenvironment studies, 5) cloud-based image storage and sharing services for national and
international cohort development. The MSTR in development will deliver this wide range of services through a
dedicated team of senior scientists with expertise in precision medicine, tissue engineering, genetic admixture,
analyte identification, bioinformatics, and multi-scale modeling.

## Key facts

- **NIH application ID:** 9849217
- **Project number:** 5P30CA033572-37
- **Recipient organization:** BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
- **Principal Investigator:** Linda H. Malkas
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $312,835
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9849217

## Citation

> US National Institutes of Health, RePORTER application 9849217, Developmental Funds (5P30CA033572-37). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9849217. Licensed CC0.

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