# The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Administrative Core

> **NIH NIH U54** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2020 · $250,970

## Abstract

PROJECT SUMMARY - EPIBIOS4RX ADMINSTRATIVE CORE
The Administrative Core for EpiBioS4Rx will serve as the central nexus for all operational aspects of the
Center without Walls (CWOW). This Administrative Core brings together the strongest teams, ensuring
success of the Cores and Research Projects to achieve the goals and objectives of EpiBioS4Rx.
Scientific Premise: Epileptogenesis after TBI can be prevented with specific treatments; the
identification of relevant biomarkers and performance or rigorous preclinical trials will permit the
future design and performance of economically feasible full-scale clinical trials of antiepileptogenic
therapies. The CWOW has special administrative requirements in order to be successful; these include the
management of each of the participating sites to ensure their efforts are complimentary, coordinated and
maximally efficient. EpiBioS4Rx will include the Administrative Core, an Informatics Analytics Core (IAC), a
Public Engagement Core (PEC), and three Research Projects focused on identification of biomarkers of
epileptogenesis, targets for novel approaches to antiepileptogenesis, and preclinical trials of potential
preventive therapies. We have now completed a three-year planning grant designed to identify available
animal and patient data that might contain biomarkers of epileptogenesis and collected and analyzed these
data, leveraging two existing bioinformatics platforms, in collaboration with other, more specialized systems.
There are protocols in place for the transfer and storage of data that will be used for the new, easily accessible
common interface.
The EpiBioS4Rx Administrative Core will oversee, coordinate, and provide logistical support for the activities of
the Cores and Research Projects, and oversee the management of the Shared Resource Facility, to provide
critical infrastructure for CWOW investigators, and to make data, reagents, methods, and other resources
available to the broader epilepsy research community. Leadership of EpiBioS4Rx will consist of a Director and
six other co-PIs, as well as Management, Executive, and Steering Committees. A Charter for the CWOW,
universal protocols, common data elements, regulatory provisions, plans for data sharing, and an Authorship
Agreement has been created. The timeline for building the new infrastructure as well as a plan for
communications and cooperation among CWOW investigators and collaborators outside the CWOW are
contained within the Charter.

## Key facts

- **NIH application ID:** 9849337
- **Project number:** 5U54NS100064-04
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** ARTHUR W TOGA
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $250,970
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9849337

## Citation

> US National Institutes of Health, RePORTER application 9849337, The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Administrative Core (5U54NS100064-04). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9849337. Licensed CC0.

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