# KLF control of aging and age-associated cardiovascular disease

> **NIH NIH R35** · CASE WESTERN RESERVE UNIVERSITY · 2020 · $951,000

## Abstract

(7) Project Summary / Abstract
Advancing age is a major independent risk factor for cardiovascular disease. The prevalence of specific
cardiovascular conditions such as cardiac hypertrophy/failure, atherosclerosis, and inflammation increase with
age. Previous studies by the applicant's laboratory illuminated essential roles for KLFs in control of immunity,
metabolism, and impact on the cardiovascular system. Nascent observations by the applicant build on the
published corpus of work and identify KLFs as a heretofore unappreciated molecular control locus
governing both lifespan and healthspan across metazoan life. The current application seeks to (a) determine
which mammalian KLFs are linked to aging, (b) determine the effect of manipulating KLF4 on cardiac and
vascular healthspan in aging mammals, and (c) determine the effect of manipulating myeloid KLF2 on
aging/age-associated inflammatory states. Completion of the outlined work will provide fundamental insights
with therapeutic implications regarding aging and age-associated cardiovascular disease.

## Key facts

- **NIH application ID:** 9849795
- **Project number:** 5R35HL135789-04
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **Principal Investigator:** MUKESH Kumar JAIN
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $951,000
- **Award type:** 5
- **Project period:** 2017-02-01 → 2024-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9849795

## Citation

> US National Institutes of Health, RePORTER application 9849795, KLF control of aging and age-associated cardiovascular disease (5R35HL135789-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9849795. Licensed CC0.

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