# Microscopy/Histopahology

> **NIH NIH P30** · BOSTON CHILDREN'S HOSPITAL · 2020 · $249,931

## Abstract

The mission of the Microscopy and Histopathology Core B is to provide access to basic and cutting-edge 
optical and electron microscopy equipment, expertise and methods for microscopy techniques, training, 
service, and histology/histopathology support for innovative and cross-disciplinary GI and liver research. Core 
B, which is located at the Beth Israel Deaconess Medical Center (site 1) and Boston Children’s Hospital (site 2) 
has the following Specific Aims: 1) to provide access to resources, technologies and services unavailable in 
members' labs, or inaccessible in other institutional cores; 2) to extend the resources of HDDC investigators 
by subsidizing the costs of services, materials and equipment use; 3) to enhance the technical capabilities of 
established and young HDDC investigators through training in advanced technologies; and 4) to research, 
develop and acquire new and emerging technologies that will accelerate digestive diseases research now and 
in the future. 
In the past 5-year funding cycle, seven services were offered for Core B. Sixteen or more HDDC members 
used one or more of the Core B services in every quarter as measured in billable hours of service. HDDC 
support significantly extended grant dollars by reducing the cost of services by 25% or more for HDDC 
members and more than 80 papers primarily benefited from core B use. New innovations and equipment 
updates in the past funding cycle benefited, in particular, the electron microscopy and confocal microscopy 
services and their users. 
In the next funding cycle, two new services are proposed for core B including advanced microscopy 
instrumentation and animal histopathology support. The electron microscopy service intends to add capacity 
for high pressure freezing/freeze substitution and the confocal service will add new instrumentation and the 
capacity for ratio imaging. Overall, fifty eight HDDC Members anticipate use of Core B in next funding cycle. 
Discounted services for HDDC members will continue to extend grant dollars and priority access for HDDC 
members to core services should facilitate greater productivity.

## Key facts

- **NIH application ID:** 9850254
- **Project number:** 5P30DK034854-35
- **Recipient organization:** BOSTON CHILDREN'S HOSPITAL
- **Principal Investigator:** WAYNE I LENCER
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $249,931
- **Award type:** 5
- **Project period:** — → 2021-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9850254

## Citation

> US National Institutes of Health, RePORTER application 9850254, Microscopy/Histopahology (5P30DK034854-35). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9850254. Licensed CC0.

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