# Regulation of the IgG Fc domain repertoire

> **NIH NIH R01** · STANFORD UNIVERSITY · 2020 · $588,222

## Abstract

PROJECT SUMMARY/ABSTRACT
IgG antibodies are central mediators of human immunity that can both protect against infections and have the
potential to mediate autoimmune diseases. While antibody-mediated immunity has been studied for decades,
the heterogeneity that exists among people in IgG-mediated effector capabilities is only now being fully
appreciated. This heterogeneity arises from differences in the structural determinants of IgG Fc domains; this,
in turn, impacts Fc-Fc receptor interactions which mediate antibody effector functions. Our ongoing
experiments have defined distinctions in immune functioning and susceptibility to diseases that arise from Fc
domain diversity. Specifically, we have found that specific Fc domain repertoires can enhance vaccine
responses and increase susceptibility to disease during dengue infection. Given these findings, a critical
question emerges: how is the Fc domain repertoire regulated? Studies in this proposal are designed to identify
regulators of the IgG Fc domain repertoire. We will define how heritable influences, age and sex influence the
repertoire. In addition, we will study how basal Fc domain repertoires impact durable B and T cell responses to
vaccination. Mechanisms regulating the Fc domain repertoire are of great interest since shifting the repertoire
could potentially be done for therapeutic benefit in diseases responsive to IVIG treatment, to enhance the
activity of anti-tumor antibodies, to prevent autoantibody-mediated tissue diseases, or to enhance the quality of
antibodies generated during vaccination.

## Key facts

- **NIH application ID:** 9850522
- **Project number:** 5R01AI139119-02
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Taia Wang
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $588,222
- **Award type:** 5
- **Project period:** 2019-01-15 → 2023-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9850522

## Citation

> US National Institutes of Health, RePORTER application 9850522, Regulation of the IgG Fc domain repertoire (5R01AI139119-02). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/9850522. Licensed CC0.

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