# Basic-Optical Biology Core (OBC)

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA-IRVINE · 2020 · $119,739

## Abstract

Core 004 - Basic - Project Summary/Abstract - Optical Biology Core (OBC) 
The Optical Biology Core consists of a self-use facility (in McGaugh Hall) and a collaboration-based methods 
development facility located in the Beckman Laser Institute and Medical Clinic (BLIMC) namely, the Laser 
Microbeam and Medical Program facility (LAMMP), a NIBIB Biomedical Technology Resource Center. The 
self-use facility contains a Zeiss LSM 780 and a LSM 700 that can image living or fixed material. A two photon 
laser for deep tissue imaging and single photon lasers for imaging all fluorophores from DAPI (405nm) to far 
red (633nm) are available on the 780. A FLIM (Fluorescence Lifetime Microscopy) detector for studying 
molecules based on their fluorescence lifetime provides a way of studying any situation that would typically 
employ FRET. Dr. Syed manages this facility and provides training and on-site trouble shooting as well as 
experimental advice. Training is also provided for the Volocity image analysis software package that is 
available on a high end work station or from individual office computers. The web link is http://obc.bio.uci.edu. 
The second arm of the OBC includes the LAMMP facility. This NIBIB Biomedical Technology Resource Center 
is available for collaborative use and protocol development using a number of microscopes and technologies 
being developed by that center. Information about the capabilities can be found at http://lammp.bli.uci.edu/. 
These include Multi Dimensional Microscopy (MDM) platforms for studying skin carcinomas, techniques to 
detect early melanoma non-invasively, and breast cancer screening using visible light (diffuse optical 
spectroscopy and imaging, DOSI) rather than X-rays. Dr. Krasieva manages this facility and is available for 
consultation and protocol development for investigators seeking new imaging applications. They are supported 
by shop facilities that allow construction and modification of imaging platforms.

## Key facts

- **NIH application ID:** 9851356
- **Project number:** 5P30CA062203-23
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **Principal Investigator:** J LAWRENCE MARSH
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $119,739
- **Award type:** 5
- **Project period:** — → 2022-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9851356

## Citation

> US National Institutes of Health, RePORTER application 9851356, Basic-Optical Biology Core (OBC) (5P30CA062203-23). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9851356. Licensed CC0.

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