# Basic-Genomics High-Throughput Facility (GHTF)

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA-IRVINE · 2020 · $110,233

## Abstract

Core 005 - Basic - Project Summary/Abstract - Genomics High-Throughput Facility (GHTF) 
A revolution has occurred in biomedicine in which genomics information is enabling faster and more accurate 
diagnoses and precise tailoring of therapeutics to patients. This revolution was triggered by developments in 
space age miniaturization of devices to enable high throughput, chemistries and spectroscopic advances for 
labeling, and use of computer technologies to advance chip-based products and parallel data processing and 
communications to enable personalized computing. This revolution is technology-driven. The first mission of 
the Genomics High Throughput Facility (GHTF) as a shared resource of the Chao Family Comprehensive 
Cancer Research Center (CFCCC) is to act as a conduit to introduce emerging genomics technologies so that 
they can be effectively accessed by the broadest spectrum of researchers. Investment in this shared resource 
by the CFCCC has been leveraged by nationally-funded instrument grants and campus cost-sharing. These 
investments have made Affymetrix microarrays, Illumina HiSeq next generation sequencing and PacBio third 
generation sequencing available to cancer researchers within one or two years of introduction to the 
workspace--long before they were commercially available for experimentally-tailored formats. These 
technologies enabled state-of-the-art research which has translated in a very short time into identification of 
unexpected roles for transcription factors, alternative splicing and polyadenylation by Cancer Center 
researchers. Introduction of the technologies at the campus level has the additional value of stimulating 
collaborations and feedback into further interdisciplinary development of these technologies. The second 
mission of the GHTF is to train a new generation of researchers in the analysis of genomics data. In the current 
funding period, DNA sequencing analysis pipelines for HiSeq and PacBio sequencing were established. A 
Bioinformatics Consulting Service was implemented to insure impact of these data on cancer research. Key 
future development priorities for CFCC researchers by the GHTF are: 1) development of a single-cell analysis 
platform and 2) expansion of bioinformatics training and analysis. Tumor populations are heterogeneous 
collections of cells and that to study them effectively requires the ability to discriminate among them. GHTF will 
introduce a microfluidic system for preparation of sequencing libraries from individual cells. The ability to 
analyze large streams of data is arguably now the limiting technology for application of genomics to cancer 
research. We made substantial progress in this area in the current funding period and now will expand these 
efforts with longer and more specialized workshops tailored to beginning and advanced applications, additional 
staff time for bioinformatics, and access to cancer-related pathway databases.

## Key facts

- **NIH application ID:** 9851358
- **Project number:** 5P30CA062203-23
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **Principal Investigator:** SUZANNE SANDMEYER
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $110,233
- **Award type:** 5
- **Project period:** — → 2022-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9851358

## Citation

> US National Institutes of Health, RePORTER application 9851358, Basic-Genomics High-Throughput Facility (GHTF) (5P30CA062203-23). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9851358. Licensed CC0.

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