# Clinical-In Vivo Functional Onco-Imaging (IVFOI)

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA-IRVINE · 2020 · $89,181

## Abstract

Core 006 - Clinical - Project Summary/Abstract - In Vivo Functional Onco-Imaging (IVFOI) 
The aim of the In-Vivo Functional Onco-Imaging (IVFOI) Shared Resource is to enhance and support basic 
and clinical cancer researchers by providing them with the necessary expertise, imaging instrumentation, and 
image analysis techniques. The current available systems include three MRI scanners (3T- human, 4T- human 
and animal, and 7T- animal) and several cutting-edge multi-modality imaging systems for small animal 
imaging: a) combined MRI- Diffuse Optical Tomography (DOT) system, b) combined MRI-SPECT (Single 
Photon Emission Computed Tomography) system, and c) hybrid X-ray microCT-Optical Tomography system. 
The 4T MRI scanner provides an open architecture for development of new imaging methods, as well as for 
integration of a second modality such as DOT to form a combined system. Besides optical imaging, we have 
built world's first MR compatible SPECT system for small animal imaging. In addition to this we have 
developed a 3-D fluorescence & bioluminescence tomography system integrated with a micro CT. These multi- 
modality imaging systems are available for general use at this point. Beyond this small animal imaging 
instrumentation, we have been working on several new multi-modality systems for breast cancer imaging, MR- 
Optical and MR-Nuclear Imaging, and we are planning to make them available for Cancer Canter members in 
the next years. These systems will support various needs of CFCCC members in designing innovative imaging 
components into their studies, providing complementary anatomical and functional information. Additionally, 
our shared resource also supports translational clinical studies, with a precise protocol execution and a high 
standard quality control. For example, we have been supporting the collection of more than 900 breast MRI 
studies with unified protocols, and as such a large database has been collected. In the next cycle we will 
continue to support such clinical studies, and also to support translational clinical research using the multi- 
modality imaging systems in our portfolio, such as to evaluate the diagnostic performance of the combined 
MRI-Optical and MR-Nuclear imaging systems for breast cancer. 
Overall, the IVFOI Shared Resource provides CFCCC Members with ready access to state-of-the-art 
technologies, consultation for design of experiments and imaging protocols, and image acquisition and data 
analysis, as well as coordination among individual projects. Through the sharing of imaging and analysis 
protocols, we can integrate various information obtained from different projects to facilitate future collaborations 
between CFCCC members and to bring together basic scientists and clinical researchers to design and 
conduct clinical translational studies.

## Key facts

- **NIH application ID:** 9851359
- **Project number:** 5P30CA062203-23
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **Principal Investigator:** GULTEKIN GULSEN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $89,181
- **Award type:** 5
- **Project period:** — → 2022-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9851359

## Citation

> US National Institutes of Health, RePORTER application 9851359, Clinical-In Vivo Functional Onco-Imaging (IVFOI) (5P30CA062203-23). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9851359. Licensed CC0.

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