# Consortium for Viral Systems Biology Technology Core

> **NIH NIH U19** · SCRIPPS RESEARCH INSTITUTE, THE · 2020 · $227,765

## Abstract

Project Summary / Abstract 
Viral hemorrhagic fevers, of which Ebola virus (EBOV) and Lassa virus (LASV) are prototypical examples, are a 
major  source  of  human  suffering.  Recent  outbreaks  have  raised  concerns  about  the  possibility  of  a  global 
outbreak. The ultimate goal of the Consortium for Viral Systems Biology (CViSB) is to define networks of host 
and  viral  factors  that  drive  clinical  outcomes  in  Ebola  virus  disease  (EVD)  and  Lassa  fever  (LF).  The 
responsibilities  and  contributions  of  the  Technology  Core  fall  into  three  main  categories:  data  generation, 
technology  development  and  standardization,  and  evaluation  and  incorporation  of  emerging  technologies. 
Although these categories are distinct, they are tightly integrated. The Core’s role as data generation hub for 
CViSB  also  mandates  that  we  continually  work  to  develop  and  improve  our  methods  and  to  rapidly 
incorporate novel technological advances to ensure that we remain a state-of-the-art, productive member of 
the Center.  
The  Technology  Core’s  Aims  are  focused  on the development, adaptation and standardization of innovative 
experimental  approaches  in  four  main  areas:  (1)  deep  characterization  of  the adaptive immune response to 
infection,  (2)  functional  profiling  of  antiviral  serum  activity,  (3)  isolation  and  characterization  of  protective 
monoclonal antibodies and (4) cost-efficient viral genome sequencing. In addition to supporting the Center’s 
Projects and contributing to the overall success of CViSB, the Technology Core will translate its  technical and 
methodological  advances  into  standardized,  reproducible  protocols  that  will  benefit  other  Centers  and  the 
broader infectious disease community.

## Key facts

- **NIH application ID:** 9851804
- **Project number:** 5U19AI135995-03
- **Recipient organization:** SCRIPPS RESEARCH INSTITUTE, THE
- **Principal Investigator:** Bryan Briney
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $227,765
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9851804

## Citation

> US National Institutes of Health, RePORTER application 9851804, Consortium for Viral Systems Biology Technology Core (5U19AI135995-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9851804. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*