# Role of OT in cortico-striatal and amygdalo-striatal facilitation of social attachment

> **NIH NIH P50** · EMORY UNIVERSITY · 2020 · $475,438

## Abstract

PROJECT SUMMARY (Project 2, Liu)
Oxytocin is important for many aspects of social cognition. However, it is far from understood how oxytocin acts
in the brain to have its effects on social perception, learning and the formation of long-term attachments. The
monogamous prairie vole (Microtus ochrogaster) is a premier animal model for studying mechanisms of attach-
ment, and oxytocin acting in various reward-related brain regions is essential for prairie voles to form pair bonds.
Yet exactly how oxytocin facilitates pair bonding by modulating the underlying neural circuitry during social inter-
actions to form bonds is unknown, pointing to a gap in our knowledge linking neurochemical to neural circuit
mechanisms of attachment. Our long-term goal is to elucidate how oxytocin modulates reward and sensory
systems underlying social information processing and learning. We focus here on a key oxytocin receptor-rich
node at the interface between these systems, the nucleus accumbens, which receives inputs from other oxytocin
receptor-dense areas, the medial prefrontal cortex (Aim 1) and the basolateral amygdala (Aim 2). Our objective
here is to determine whether manipulating the oxytocin system to impair or enhance pair bonding affects nucleus
accumbens' functional connectivity with its mPFC and BLA inputs. Our central hypothesis is that oxytocin nor-
mally acts to improve communication from reward and cue processing areas to local NAc circuits that integrate
these channels of information during specific social interactions, helping to reinforce the ability of partner signals
to elicit affiliative behavior. We validate this hypothesis using both loss-of-function and gain-of-function experi-
mental designs, as well as optogenetics to test causality. The rationale for our proposal is that, once we know
how oxytocin affects neural circuitry between brain areas to facilitate the formation of a selective attachment, we
can begin to elucidate the molecular mechanisms for plasticity within these circuits.

## Key facts

- **NIH application ID:** 9851937
- **Project number:** 5P50MH100023-08
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Robert C Liu
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $475,438
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9851937

## Citation

> US National Institutes of Health, RePORTER application 9851937, Role of OT in cortico-striatal and amygdalo-striatal facilitation of social attachment (5P50MH100023-08). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9851937. Licensed CC0.

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