# The Cause of Systemic Inflammatory Response during Cardiopulmonary Bypass and Prevention by Nitric Oxide

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $663,177

## Abstract

Abstract
Systemic Inflammatory Response and organ failure (SIRS-CPB) is a major problem following cardiac surgery.
The incidence increases with the amount of time on cardiopulmonary bypass. The mechanism is unknown. Our
preliminary studies indicate that white cell activation by surface exposure during CPB is the cause. Our studies
indicate that the white cell activation can be prevented by nitric oxide (NO) in the gas to the heart/lung machine.
This research is designed to determine the cause of SIRS-CPB and prevention with NO.

## Key facts

- **NIH application ID:** 9851949
- **Project number:** 5R01HL141509-02
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Alvaro Rojas-Pena
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $663,177
- **Award type:** 5
- **Project period:** 2019-02-01 → 2023-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9851949

## Citation

> US National Institutes of Health, RePORTER application 9851949, The Cause of Systemic Inflammatory Response during Cardiopulmonary Bypass and Prevention by Nitric Oxide (5R01HL141509-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9851949. Licensed CC0.

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