# Mechanisms & risk factors of chronic lung disease in HIV+ adolescents in Nairobi

> **NIH NIH K23** · UNIVERSITY OF WASHINGTON · 2020 · $177,502

## Abstract

PROJECT SUMMARY/ABSTRACT
Candidate: Dr. Attia's long-term goal is to improve lung health globally, conducting clinical research and trials
in chronic lung diseases, with a focus on the role of HIV and other risk factors in influencing the
pathophysiology and clinical course of lung disease. The research proposed in this application builds on her
previous work, which found a significantly greater prevalence of chronic respiratory symptoms and abnormal
spirometry among HIV+ adolescents compared to adults in a resource-limited setting. This K23 Career
Development Award will provide Dr. Attia with essential research training to support her goal of becoming an
independent investigator at the intersection of pulmonary disease, HIV and global health. Through this project,
Dr. Attia will accomplish her immediate goals of attaining the expertise outlined in the following learning
objectives: 1) training in measurement and analysis of lung growth in adolescents; 2) design and
implementation of longitudinal studies; 3) quality control and monitoring of prospective studies; 4) advanced
biostatistical methods to analyze complex data; and 5) responsible implementation of research activities in an
international setting. These objectives will be achieved through a structured career development plan that
incorporates formal coursework, mentoring by an advisory committee with collective expertise in pulmonary
disease and lung growth, HIV, pediatrics, epidemiology, biostatistics and the use of biospecimens in clinical
research, as well as protected time to gain practical research experience.
Environment: The rich academic environment at the University of Washington (UW) is an ideal place for Dr.
Attia's continued research training. UW is an outstanding biomedical research institution with a strong
commitment to promoting the academic careers of promising investigators. The UW Division of Pulmonary and
Critical Care Medicine is widely recognized for its Clinical Research Training Track and offers an intellectual
environment that supports development of the skills necessary to collaborate with other investigators and
achieve academic success. In addition to the resources and support provided within the Division, Dr. Attia will
also have full access to the resources of the UW Department of Global Health Teaching, Research and Expert
Education (TREE) program (directed by her co-mentor), which provides the administrative, clinical, laboratory
and database management infrastructure that supports clinical research at the UW-affiliated Coptic Hope
Center for Infectious Diseases in Nairobi, Kenya. Dr. Attia will receive directed training and mentoring in
obtaining and analyzing spirometry in adolescents as a measure of lung growth and development through the
resources of the UW Department of Pediatrics and the UW-led multi-site cystic fibrosis clinical trials network,
Cystic Fibrosis Therapeutics Development Network. Dr. Attia will also have access to clinical research and
...

## Key facts

- **NIH application ID:** 9852375
- **Project number:** 5K23HL129888-04
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Engi Farouk Attia
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $177,502
- **Award type:** 5
- **Project period:** 2017-02-15 → 2022-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9852375

## Citation

> US National Institutes of Health, RePORTER application 9852375, Mechanisms & risk factors of chronic lung disease in HIV+ adolescents in Nairobi (5K23HL129888-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9852375. Licensed CC0.

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