# Animal Model/Pathology Core

> **NIH NIH P20** · KANSAS STATE UNIVERSITY · 2020 · $271,107

## Abstract

Project Summary:
The main goal of the Animal Model/Pathology (AMP) Core is to provide expert support for animal research within
the Center on Emerging and Zoonotic Infectious Diseases (EZID), including the selection of appropriate models,
biosafety and IACUC compliance submissions, and advanced, personalized pathology services for a variety of
species. The AMP Core will oversee and support all animal experimentation and post experimental
pathology evaluations performed by EZID project leaders (PLs). Animal experiments will be conducted in
Kansas State University (KSU) animal facilities located in Coles Hall in the College of Veterinary Medicine (CVM)
and at the Biosecurity Research Institute (BRI). Vivarium rooms at Coles Hall provide the capability to conduct
research with rodents and other small vertebrates in BSL-2 containment. Animal research space at the BRI
includes BSL-3Ag animal rooms and an ABSL-3 vivarium. BRI facilities allow work with select agents, including
zoonotic pathogens for animal experiments at BSL-3 level of containment. The main focus of the AMP Core will
be supporting on-going primary and pilot/seed projects of the EZID COBRE Center involving animal studies and
pathology analysis. All support will be personalized and project-specific with the focus to satisfy specific animal
research needs of the individual EZID PLs. The AMP Core will provide assistance and expertise in appropriate
study designs and in preparing and obtaining IACUC approval. The Core will also coordinate with the
Comparative Medicine Group (CMG; responsible for animal and veterinary care) and BRI timelines and space
allocation. The AMP Core will oversee and support the execution of animal studies conducted by the Center's
primary and pilot/seed PLs and their teams. The Core will also develop and conduct pilot studies on development
of challenge models in rodents and other small animals essential for EZID Center projects. For pathological
evaluations, the AMP Core will utilize expertise and equipment available in the Department of Diagnostic
Medicine/Pathobiology. All pathologic evaluations, tissue collections, and testing will be done under the oversight
of the AMP Core Associate Director, a board-certified pathologist. Existing infrastructure will be enhanced by
adding new equipment and services to expand capabilities of the Core and ensure its sustainability. This includes
the acquisition of a laser capture microdissection instrument which will allow significant synergy between the two
COBRE cores and for the first time at KSU the performance of single-cell RNA-Seq experiments. The AMP Core
will also produce hybridomas and hyper-immune sera for the development of diagnostic tests essential to
COBRE research projects. This work will be done in coordination with the Molecular and Cellular Biology Core
to ensure that appropriate sample testing methodology is developed and available for testing of the generated
antibodies. Successful implementation of the AM...

## Key facts

- **NIH application ID:** 9852899
- **Project number:** 1P20GM130448-01A1
- **Recipient organization:** KANSAS STATE UNIVERSITY
- **Principal Investigator:** Igor Morozov
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $271,107
- **Award type:** 1
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9852899

## Citation

> US National Institutes of Health, RePORTER application 9852899, Animal Model/Pathology Core (1P20GM130448-01A1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9852899. Licensed CC0.

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