# Animal Models of Digestive Disease Core

> **NIH NIH P20** · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2020 · $209,920

## Abstract

Animal Models of Digestive Disease Core – Project Summary
The objective of the Center of Biomedical Research Excellence (COBRE) in Digestive & Liver Diseases (CDLD)
is to enhance research infrastructure and expand research capacity to enable outstanding and collaborative
biomedical research in digestive and liver diseases. We wish to establish and sustain the CDLD as the driving
force for digestive and liver diseases research at the Medical University of South Carolina (MUSC). We further
envision that the MUSC CDLD will become a major focal point for digestive and liver diseases in the state of
South Carolina, becoming a hub for trainees and established investigators alike. The topic of this COBRE is
particularly relevant given the enormous impact of digestive and liver diseases on a broad range of Americans,
including the citizens of South Carolina.
Performance of digestive disease research requires utilization of unique and complex models of disease. Thus,
we have developed a Core intended to specifically provide the COBRE in Digestive & Liver Diseases (CDLD)
with a distinctive, unified, and skilled core facility that provides access to essential animal models and guidance
on research project planning and implementation. The proposed core will leverage existing resources and
expertise within the MUSC Division of Laboratory Animal Resources (DLAR) in order to efficiently develop new
capabilities that focus on producing in vivo models of digestive disease. Core leaders will offer CDLD Junior
Investigators (JIs) specialized knowledge, mentorship and training on animal models so that they obtain
sufficient, high quality data for their projects, which will then form the basis of their successful competition for
future independent extramural funding. Supporting JIs’ research is the a objective for the AMDDC; however, all
investigators at MUSC will have access to the models, resources, and training the Core provides.
To achieve the stated objective, the AMDDC will be composed of three distinct but interactive components as
follows: 1) Animal models of digestive and liver diseases, 2) A gnotobiotics facility, and 3) A focused and
extensive training and mentoring component. Members of this core are skilled and highly experienced,
supporting the generation of high quality data.
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## Key facts

- **NIH application ID:** 9853388
- **Project number:** 1P20GM130457-01A1
- **Recipient organization:** MEDICAL UNIVERSITY OF SOUTH CAROLINA
- **Principal Investigator:** Suzanne L Craig
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $209,920
- **Award type:** 1
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9853388

## Citation

> US National Institutes of Health, RePORTER application 9853388, Animal Models of Digestive Disease Core (1P20GM130457-01A1). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9853388. Licensed CC0.

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