# Functional Genomic Core

> **NIH NIH P30** · DUKE UNIVERSITY · 2020 · $76,454

## Abstract

ABSTRACT – FUNCTIONAL GENOMICS SHARED RESOURCE
 The Functional Genomics (FG) shared resource was a developing shared resource and is being submitted
as a new Duke Cancer Institute (DCI) – CCSG Shared Resource. Functional Genomics supports Duke Cancer
Institute investigators by providing a broad range of services to facilitate the application of functional genomics
technologies, including CRISPR/Cas9, RNAi- and ORF-based approaches.
 Through investments in genetic and chemical perturbagen collections and high-throughput screening
infrastructure, we have assembled state-of-the-art technological platforms for functional studies in both high-and
low-throughput applications. The FG provides expertise and assistance in developing and implementing genetic
screens in arrayed or pooled format, as well as custom services for the creation of individual knock-out, knock-
in or overexpression experimental models. In addition, FG enables screening of diverse compound collections
with either cell-based or biochemical assays for chemical genetic or drug discovery studies. FG also provides
access to advanced instrumentation for screen-related or standalone assays, including multimodal plate readers
and a high-content screening (HCS) system for image-based analysis. Finally, the FG is dedicated to developing
and adapting new functional genomic techniques and reagents to better support the needs of DCI investigators,
enabling them to keep pace with the rapidly evolving field of functional genomics.
 In 2018, Functional Genomics provided services to 60 investigators, 58% of whom were DCI members who
accounted for 66% of total usage and represented 7 of the 8 DCI Research Programs. Use of the shared
resource by DCI members contributed to 24 publications over the current project period, 11 of which were in
high impact journals (Impact Factor>9), demonstrating the value of services offered by this new resource.

## Key facts

- **NIH application ID:** 9853593
- **Project number:** 2P30CA014236-46
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** So Young Kim
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $76,454
- **Award type:** 2
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9853593

## Citation

> US National Institutes of Health, RePORTER application 9853593, Functional Genomic Core (2P30CA014236-46). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9853593. Licensed CC0.

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