# Core B

> **NIH NIH U19** · BETH ISRAEL DEACONESS MEDICAL CENTER · 2020 · $378,401

## Abstract

Core B (Immunology Core) will provide standardized humoral immune monitoring assay services for
evaluating antibody responses elicited by Ad26-Env/Gag/Pol prime, Env gp140 protein boost (Ad26/Env)
vaccine regimens in the studies described in this IPCAVD program. Core B leadership will work closely
with investigators responsible for the studies described in Project 1 and Project 2 and will participate actively in
the scientific mission of the overall IPCAVD program. The primary goal of Core B is to provide the leadership
and the technical expertise to ensure that all vaccine-induced humoral responses will be profiled in a
standardized fashion and that the IPCAVD leadership is kept abreast of the latest developments in assessing
vaccine-induced neutralizing and non-neutralizing humoral immunity, particularly in relation to their ability to
prevent viral infection. To accomplish these goals, we propose the following three Specific Aims:
Specific Aim 1. To perform standardized neutralizing antibody (NAb) assays in both NHP and humans
Specific Aim 2. To perform standardized non-neutralizing antibody assays in both NHP and humans
Specific Aim 3. To integrate all antibody data into a Systems Serology profiling approach to define correlates
of protective immunity

## Key facts

- **NIH application ID:** 9853725
- **Project number:** 5U19AI128751-03
- **Recipient organization:** BETH ISRAEL DEACONESS MEDICAL CENTER
- **Principal Investigator:** Galit Alter
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $378,401
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9853725

## Citation

> US National Institutes of Health, RePORTER application 9853725, Core B (5U19AI128751-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9853725. Licensed CC0.

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