# Administrative Core

> **NIH NIH P01** · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2020 · $124,489

## Abstract

CORE A- SUMMARY/ABSTRACT
Our ultimate goal of this program grant is to gain a better understanding of the heterogeneous pathogenesis of
AD and how it is influenced by apolipoprotein (apo) E isotypes, using human tissue, with correlations to
findings in various AD models, using proteomic and other methods which we have recently developed. In
particular we are focusing on the differential role apolipoprotein E (apoE) isoforms play in: 1) AD plaque and
vessel amyloid development (Project 1); 2) therapeutic approaches that target the Aβ/apoE interaction (Project
2); 3) responses to therapeutic immunomodulation targeting abnormal conformation (Project 3). The
Administrative Core (Core A) is charged with ensuring the success of this research proposal. The Aims are:
Aim 1. Provide administrative structure and fiscal oversight for the program project grant.
Aim 2. Organize regular meetings of the Executive Committee (EC) composed of Project and Core Leaders
and other key personnel to assist in scientific administration and to facilitate integration and continuing
progress on research aims.
Aim 3. Coordinate with the bioinformatics/statistical/data management Core D to ensure optimal data
utilization and scientific rigor for the Program Project.
Aim 4. Interact closely with the External Advisory Committee and Internal Advisory Board, and conduct regular
meetings of both. The External Advisory Committee and Internal Advisory Board will provide scientific advice
and guidance for all research projects.
Aim 5. Report progress to NIH and ensure compliance with the NIH Public Access policy.
Aim 6. Promote education on AD and related disorders, and facilitate P01 scientists’ participation in education
to researchers, clinicians and patients/caregivers.

## Key facts

- **NIH application ID:** 9853941
- **Project number:** 1P01AG060882-01A1
- **Recipient organization:** NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- **Principal Investigator:** THOMAS M WISNIEWSKI
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $124,489
- **Award type:** 1
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9853941

## Citation

> US National Institutes of Health, RePORTER application 9853941, Administrative Core (1P01AG060882-01A1). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9853941. Licensed CC0.

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