# Career Enhancement Core

> **NIH NIH U54** · BRIGHAM AND WOMEN'S HOSPITAL · 2020 · $269,591

## Abstract

PROJECT SUMMARY
The overarching goal of the proposed Brigham/Harvard Center for Stress and Neural Regulation of Reproductive
Aging Health Outcomes is to investigate the role of stress and its neural mechanisms in reproductive aging
health outcomes that confer susceptibility to cardiovascular disease and dementia in aging women, and to
catalyze growth of interdisciplinary and translational women’s health and sex-differences research. Within this
framework, the proposed Career Enhancement Core (CEC) will be responsible for the integration of cross-Center
and Harvard-wide expertise to provide a rich research and learning environment for training the next generation
of investigators in women’s health and sex differences in stress, sleep, cognitive decline, cardiometabolic
disease and neural regulation research. The CEC is uniquely placed to leverage strong existing institutional
programs and infrastructure in addition to developing an interdisciplinary training and mentorship program. The
specific aims of the CEC are: 1) To fund cutting-edge SCORE Scholars and Pilot Projects to promising early-
career investigators or established investigators who are gaining new skills in stress, neural regulation, and
sleep, to foster sex/gender and women’s health research in reproductive aging health outcomes relevant to
cardiovascular disease and dementia in postmenopausal women; 2) To train CEC participants in a robust
educational program in sex-differences research methods, transparency, and rigor, as well as support Travel
Exchange Fellowships to foster learning and collaboration with the national SCORE research network; and 3)
To disseminate knowledge from these educational programs and research methods to the local and wider
national community through webinars, publications, and online educational forums. Achieving these aims will not
only advance the mission of our SCORE but will also promote the development of a new cadre of investigators
in the field. The CEC will work closely with all the Brigham/Harvard SCORE Projects, SRC, and LAC to leverage
robust existing research infrastructure in women’s health, sleep medicine, neuroscience, stress science, and
cardiometabolic disease to meet career enhancement needs for participants. Additionally, the CEC will build a
robust educational resource for the Brigham/Harvard community and the larger SCORE community.

## Key facts

- **NIH application ID:** 9854037
- **Project number:** 1U54AG062322-01A1
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** KATHRYN M REXRODE
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $269,591
- **Award type:** 1
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9854037

## Citation

> US National Institutes of Health, RePORTER application 9854037, Career Enhancement Core (1U54AG062322-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9854037. Licensed CC0.

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