# Resource Support Core

> **NIH NIH U54** · YALE UNIVERSITY · 2020 · $167,500

## Abstract

Rates of alcohol use disorders (AUDs) in women have increased by 84% over the last decade, relative to the
35% increase in men. The Resource Support Core of the Yale-SCORE is designed to support the dramatic
need for translational research to address the concerning increase in rates of AUD among women. The key
purpose of the Resource Support Core is to provide essential research-related resources to Yale-SCORE
investigators, trainees, and collaborating researchers. The resources provided will serve to maximize the
quality of the data, the comparability of data across Projects, and increase dynamic communication among
Yale-SCORE researchers to maximize the translation of results across projects and within the greater research
environment. The Core will: 1) Provide expert consultation, management, and coordination of IRB/IACUC
approvals, regulatory procedures and data safety monitoring, as required for animal and human Projects and
Pilots. 2) Generate comprehensive strategies to recruit equal numbers of women and men and ensure
racial/ethnic minority diversity in samples of human subjects into all Yale-SCORE clinical studies. Ensure that
equal numbers of female and male animals are studied in preclinical projects. 3) Provide modern data
management and analytical techniques that incorporate state-of-the-art SABV approaches across the
conceptualization, methods, analysis, and reporting of all Yale-SCORE findings. 4) Provide centralized training
and quality control of core assessments and assays across animal and human studies to maximize the
scientific yield across studies. 5) Incorporate an innovative biosensor system into Yale-SCORE human projects
to provide a wealth of data to examine sex differences in ‘real-world’ naturalistic drinking behavior (e.g., blood
alcohol levels, drinking topography) and context of drinking (e.g., time, location, activity, social milieu) in
women and men meeting criteria for AUD. This will be the first ever dataset of its kind, providing an estimated
3 billion data points. 6) Leverage available national big-data resources to expand our T1 to T4 translational
focus on sex differences in alcohol use.

## Key facts

- **NIH application ID:** 9854090
- **Project number:** 1U54AA027989-01
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Ralitza Gueorguieva
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $167,500
- **Award type:** 1
- **Project period:** 2020-03-10 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9854090

## Citation

> US National Institutes of Health, RePORTER application 9854090, Resource Support Core (1U54AA027989-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9854090. Licensed CC0.

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