# Core B

> **NIH NIH P01** · BETH ISRAEL DEACONESS MEDICAL CENTER · 2020 · $201,619

## Abstract

PROJECT SUMMARY – Core B
The major goals of the Molecular Biology Core is to provide expert and efficient laboratory services to Project 1
(Saper), Project 2 (Scammell), Project 3 (Fuller) and Project 4 (Dymecki/Vanderhorst). We also anticipate that
our transcriptomics work will inform selective pharmacological targets for Project 5 (Wellman). The major
duties of Core B are management and genotyping of mutant mouse colonies, performing in situ hybridization
(RNAscope), preparation of viral vectors, including the development of new genetic constructs, and performing
single cell (scRNA-seq) and single nuclei transcriptomics (sNuc-seq), including assistance with bioinformatic
analysis of the transcriptomics datasets. By providing these centralized services, Core B will maximize the
chance of success with several of the more complicated molecular techniques proposed in this PPG. Our
years of experience with these methods maximizes the likelihood that the complicated molecular techniques
proposed in this PPG will succeed.

## Key facts

- **NIH application ID:** 9854430
- **Project number:** 1P01HL149630-01
- **Recipient organization:** BETH ISRAEL DEACONESS MEDICAL CENTER
- **Principal Investigator:** Patrick M Fuller
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $201,619
- **Award type:** 1
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9854430

## Citation

> US National Institutes of Health, RePORTER application 9854430, Core B (1P01HL149630-01). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9854430. Licensed CC0.

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