# National Resource for Translational and Developmental Proteomics

> **NIH NIH P41** · NORTHWESTERN UNIVERSITY · 2020 · $1,967,464

## Abstract

Overall
Abstract
The National Resource for Translational and Developmental Proteomics, or NRTDP, proposes a constellation of
activities in its second phase of operation. After launching in 2015 and establishing functional programs in each
mission of a P41 BTRR, we now turn toward the proposed granting period from 2020 – 2025 to develop new
technologies and translate them by enabling both practitioners to analyze proteoforms and many collaborators
to understand their biology more deeply. Consistent with changes in the P41 program, we place major emphasis
on enabling basic and clinical research in proteomics, reduction to practice to extend innovations to early
adopters of new implementations of top-down proteomics, which is itself a new concept to many we
encounter. We also embrace mechanisms including corporate partnerships, community engagement, training
and dissemination to ensure a sustainable impact even after the sunset of this P41 National Resource.
After booting up our operation, we now posit three new Technology Research and Development Projects, six
new Driving Biomedical Projects, a highly dynamic set of collaborative projects and an array of Community
Engagement activities to continue serving our unique role within the set of P41 Resources currently supported
by NIGMS. The technology and support emanating from our resource will continue to provide collaborators with
orthogonal data streams and further demonstrate the value of measuring proteins more precisely than is possible
with current-generation technology of “bottom-up” proteomics. From heart disease to cancer research,
neurology and age-related disorders to immunology, the analysis of proteins and proteoforms and their post-
translational modifications will continue to unveil underlying molecular mechanisms through new and cell-specific
technologies for precision proteomics. This will enable clinicians and cell biologists across four major disease
areas, and significantly bolster American interests with an internationally-recognized excellence in a new style
of mass spectrometry-based proteomics that complements existing areas of investment across the nation. The
geographical distribution of collaborators and training activities are consistent with a mature resource that
reaches the level of operation envisaged in the original grant proposal in 2015.
The institutional support is very strong from an environment of Northwestern University on both its basic science
and medical research campuses in the greater Chicago area. Leveraging a team of professional proteomicists
with diverse backgrounds and experiences, the NRTDP has proven to be a highly capable enterprise that returns
strongly on programmatic support received by NIGMS. As a unit, we place high value on attentiveness to the
spirit and the letter of the P41 program, and also seek to synergize with other P41s within the current portfolio
supported by the NIGMS and NIH.

## Key facts

- **NIH application ID:** 9854763
- **Project number:** 2P41GM108569-06
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** NEIL L KELLEHER
- **Activity code:** P41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,967,464
- **Award type:** 2
- **Project period:** 2015-08-01 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9854763

## Citation

> US National Institutes of Health, RePORTER application 9854763, National Resource for Translational and Developmental Proteomics (2P41GM108569-06). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9854763. Licensed CC0.

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