# Chemical and Structual Biology

> **NIH NIH P30** · UNIVERSITY OF VIRGINIA · 2020 · $33,954

## Abstract

CHEMICAL AND STRUCTURAL BIOLOGY (CSB) – PROJECT SUMMARY/ ABSTRACT 
Detailed understanding of molecular function in biological systems requires information about the 3D structures 
of macromolecules. The wealth of information available from such studies provides novel and powerful 
insights into function. Chemical biology, the modulation of protein function by small molecules, provides tool 
compounds to explore biological function as well as novel therapeutics for the clinic. The tools of imaging, 
detection, and drug delivery emerge from chemical biology efforts. The merging of the structural biology and 
chemical biology faculty brings together two groups that speak the same language, the language of molecular 
structure, making this a natural grouping. The overarching goal of the Chemical & Structural Biology (CSB) 
Program is to facilitate this dialogue in ways that accelerate understanding, detection, and treatment of cancer. 
The Program leader is John H. Bushweller, PhD, Professor of Molecular Physiology and Biological Physics, 
and the co-leader is Kevin R. Lynch, PhD, Professor of Pharmacology and Biochemistry & Molecular Genetics. 
The Program currently consists of 23 members and 6 associate members from seven different departments 
spanning three different schools at UVA. This includes the Chemistry Department, providing unique cross- 
campus opportunities to bring the power of chemistry to bear on cancer. Six of these individuals were 
recruited to UVA since the last renewal. Total extramural funding for the Program exceeds $12M, including 
over $2.4M from the NCI and over $8.7M from other NIH institutes. The group members rely heavily on Cancer 
Center supported infrastructure, particularly the Biomolecular Analysis Core and NMR instrumentation. Pilot 
grant support of CSB members has shown a clear return on investment with several NCI funded grants 
emerging from work supported originally with pilot grant support. The many activities and interactions have led 
to 276 publications, of which 18% were inter-programmatic publications and 18% were intra-programmatic 
publications since the last renewal.

## Key facts

- **NIH application ID:** 9854918
- **Project number:** 5P30CA044579-29
- **Recipient organization:** UNIVERSITY OF VIRGINIA
- **Principal Investigator:** JOHN Hackett BUSHWELLER
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $33,954
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9854918

## Citation

> US National Institutes of Health, RePORTER application 9854918, Chemical and Structual Biology (5P30CA044579-29). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9854918. Licensed CC0.

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