# Metabolic Pathways Underlying the Contrasting Sodium-BP and DASH/OmniHeart-BP Relationships

> **NIH NIH R01** · NORTHWESTERN UNIVERSITY · 2020 · $602,081

## Abstract

Project Summary
The GENERAL AIM of this proposal is to qualitatively advance knowledge on urinary metabolic
phenotypes and biochemical pathways associated with the direct effect on blood pressure (BP)
of high sodium (Na) intake and the inverse BP effect (BP reduction) of the DASH/OmniHeart-
like eating pattern. To achieve this aim, we will identify and quantify key metabolites related to
these contrasting BP influences, and use state-of-the-art chemometrics, statistical
spectroscopy, computational network and pathway modeling tools to identify and map de novo
pathways associated with Na-BP and DASH/OmniHeart-BP. We will then test and validate the
INTERMAP derived metabolites and pathways using available data and samples from the
INTERMAP China Prospective (ICP) Study, the Urinary Sodium Study (USS), and the
OmniHeart Trial. The goal is to develop more focused and effective strategies for population-
wide BP lowering through improved non-pharmacologic approaches, primarily nutritional, as
well as to identify new targets for drug intervention. To our knowledge, this is the first
investigation to identify urinary metabolites and associated pathways related to Na-BP and
DASH/OmniHeart-BP, link these to dietary and other data, and with extensive validation in other
cohorts, prospective and trial data.

## Key facts

- **NIH application ID:** 9855065
- **Project number:** 5R01HL135486-04
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** Martha L Daviglus
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $602,081
- **Award type:** 5
- **Project period:** 2017-02-01 → 2023-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9855065

## Citation

> US National Institutes of Health, RePORTER application 9855065, Metabolic Pathways Underlying the Contrasting Sodium-BP and DASH/OmniHeart-BP Relationships (5R01HL135486-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9855065. Licensed CC0.

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