# Genomic and Molecular Biology (GMB)

> **NIH NIH P30** · DARTMOUTH COLLEGE · 2020 · $200,777

## Abstract

Project Summary/Abstract: Genomics and Molecular Biology
The Genomics and Molecular Biology (GMB) Shared Resource provides advanced genomics technologies,
services, and expertise in support of biomedical research conducted at the Norris Cotton Cancer Center
(NCCC) and Dartmouth College. GMB operates as a fee-for-service facility offering sequencing of DNA and
RNA, microarray technologies, single-cell DNA/RNA sequencing, NanoString assays, and next-day Sanger
sequencing services. GMB also provides expertise for assay design and primary data analysis as
complementary services. Improvements to GMB in the past several years include a new and improved sample
tracking and billing system (RaDar), as well as up-grades in instrumentation and protocols used. Additional
improvements include added expertise of new personnel and services for single-cell sequencing, new
Nanostring assays, and mouse SNP genotyping. GMB and its committed staff have a combined 130+ years of
clinical- and research-related laboratory experience. This expertise and experience facilitate GMB’s ability to
operate state-of-the-art instrumentation and implement cutting-edge workflows, providing NCCC researchers
with access to essential genomics technologies in this fast-moving field. It is also essential for GMB to stay
competitive with market rates while providing additional value to its users over external service providers.
Strong institutional support and GMB leadership ensure its stability. GMB leadership works diligently to recruit
new projects to the shared resource through participation in both internal and external seminars and
conferences. Personnel within GMB stay abreast of new technology developments through conference
attendance as well as membership in the Association of Biomolecular Research Facilities (ABRF). GMB serves
Cancer Center members, the broader Dartmouth research community, and users from outside institutions,
operating at ~80% capacity. Sixty-one (61) NCCC Members from all 4 NCCC Programs utilized the GMB
Shared Resource, 60 of whom are current Members in 4 Programs (CPS [6], CBT [37], ICI [14], and TEC [3]).
NCCC Funded Member Use represented 31% of Total Use (4,779 Projects), and we are requesting 19% of the
GMB Total Operating Budget from CCSG support. Priority is given to NCCC member samples, followed by
Dartmouth samples, and then outside samples. GMB maintains stringent quality control procedures over
samples entering and data leaving the facility. Appropriate controls are run regularly on all instrumentation, and
run metrics are tracked over time to ensure optimal performance. Future plans involve implementing new
single-cell workflows highly sought by NCCC researchers, protein and antigen barcoding, and DNA and ATAC-
seq workflows. Talks are underway to acquire spatial genomic technologies, such as the Nanostring Digital
Spatial Profiler, as a complement to droplet-based single-cell profiling. GMB is implementing solutions for
genome-wide detection of...

## Key facts

- **NIH application ID:** 9855306
- **Project number:** 2P30CA023108-41
- **Recipient organization:** DARTMOUTH COLLEGE
- **Principal Investigator:** CRAIG R TOMLINSON
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $200,777
- **Award type:** 2
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9855306

## Citation

> US National Institutes of Health, RePORTER application 9855306, Genomic and Molecular Biology (GMB) (2P30CA023108-41). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9855306. Licensed CC0.

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