# Protocol Review and Monitoring System (PRMS)

> **NIH NIH P30** · DARTMOUTH COLLEGE · 2020 · $70,986

## Abstract

Project Summary/Abstract: Protocol Review and Monitoring System
The Norris Cotton Cancer Center (NCCC) has established a process by which clinical trials/population science
studies proposed by Cancer Center Members undergo internal peer review. This review must occur prior to
local Institutional Review Board (i.e., the Dartmouth College Committee for the Protection of Human Subjects
[CPHS]) submission and review. The protocol review and monitoring system is overseen by the protocol
review and monitoring committee (PRMC) which at NCCC is known as the Clinical Cancer Review Committee
(CCRC). The CCRC is responsible for assessing the scientific validity of proposed studies, determining their
prioritization and feasibility in light of the availability of human subjects and current protocols relying on
enrollments from that same patient population, assuring that the safety monitoring plan is appropriate and in
accordance with regulations, and where necessary offering constructive comments that enhance either
scientific merit or implementation logistics of the proposed clinical study.
The NCCC CCRC is a chartered multidisciplinary committee charged with reviewing all non-NCI Cooperative
group research protocols and amendments proposed to be opened by Dartmouth Principal Investigators (PIs)
for treatment of, and intervention for, cancer. Cancer prevention studies, screening trials, behavioral studies,
quality of life/survivorship studies, and interventional trials that rely on collection of patient-reported outcomes
that have not already undergone external peer review by NIH and its funding agencies are reviewed by the
Population Science Subcommittee (PSS) of the CCRC. The CCRC has the ultimate authority to approve,
require modifications, or disapprove of research activities and terminate studies that fall within its jurisdiction.
Situations where CCRC will close studies include when they have a negative safety outcome, have low
accrual, or if the study will not achieve its scientific objectives.
CCRC members are selected to represent the broad spectrum of oncology expertise. Cadre membership
includes representatives from medical oncology, hematology, surgical oncology, pediatric oncology, clinical
pharmacology, biostatistics, basic science research, population science, clinical research administration, and
research participant advocacy. Other disciplines, such as Radiation Oncology, Pathology, Immunology and
translational biomedical engineering, are represented by members on an ad-hoc basis when a proposed
clinical trial features such components in its main objectives.

## Key facts

- **NIH application ID:** 9855320
- **Project number:** 2P30CA023108-41
- **Recipient organization:** DARTMOUTH COLLEGE
- **Principal Investigator:** LIONEL David LEWIS
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $70,986
- **Award type:** 2
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9855320

## Citation

> US National Institutes of Health, RePORTER application 9855320, Protocol Review and Monitoring System (PRMS) (2P30CA023108-41). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9855320. Licensed CC0.

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