# Structural Biology

> **NIH NIH P30** · SLOAN-KETTERING INST CAN RESEARCH · 2020 · $541,045

## Abstract

ABSTRACT
The goal of Structural Biology (SB) Core (formerly X-Ray Crystallography Core) is to provide access to
expertise as well as state-of-the-art equipment and software to Center laboratories that address structural
questions within their research. Understanding the biological processes involved in tumorigenesis has
increasingly benefitted from structural investigations that provide key functional and mechanistic insights, as
well as atomic-level details important for drug discovery. Many of the questions require the structure
determination of large proteins, assemblies and macromolecular machines. The Core maintains in house
equipment (Rigaku Micromax 007hf diffractometer and Titan Krios-Gatan K2 cryo electron microscope) and
computational resources for data collection, processing and structure determination, including graphical
workstations and a high-performance Linux cluster. The SB Core implements a range of software packages for
structural determination and analysis, participates in multi-institutional consortia for access to synchrotron
beamlines and cryoEM and provides training and assistance to users. In addition, the Core Head collaborates
with non-structural MSK groups on macromolecular crystallization and structure-determination projects, and
also provides modeling expertise and guidance to those labs that can benefit from the use of available
structures in the design and interpretation of experiments. The SB Core has supported 9 investigators in the
past year and has contributed to 127 publications of investigators from 3 programs.

## Key facts

- **NIH application ID:** 9858282
- **Project number:** 5P30CA008748-54
- **Recipient organization:** SLOAN-KETTERING INST CAN RESEARCH
- **Principal Investigator:** Yehuda Goldgur
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $541,045
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9858282

## Citation

> US National Institutes of Health, RePORTER application 9858282, Structural Biology (5P30CA008748-54). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9858282. Licensed CC0.

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