# PRODUCTION CENTER FOR MAPPING REGULATORY REGIONS OF THE HUMAN GENOME

> **NIH NIH UM1** · STANFORD UNIVERSITY · 2020 · $4,223,046

## Abstract

ABSTRACT
Although our ability to determine the genome sequence of individuals is becoming facile, our
understanding of the function of most of the human genome is limited. Mapping of regulatory information
is particularly crucial since most (>85%) common variants associated with human disease lie outside of
coding regions. Previous phases of ENCODE have made important contributions to the mapping of
regulatory elements across the genome, but there is much more to be acheived, including the mapping
of regulatory regions across many more tissues and at the resolution of individual cells as well as
determining the exact regulators i.e. transcription factors that bind each region. In our Stanford
ENCODE Production Center for Mapping of Regulatory Regions, we plan to use technologies that we
have developed to map the binding sites for most transcription factors (TFs) in five major cell lines using
chromatin immunoprecipitation of tagged TFs. We will further expand the catalog of regulatory elements
by analyzing open chromatin regions in these cell lines and a wide variety of tissues and cell types from
both normal and diseased human subjects consented for open access. Finally, we will map open
chromatin regions in single cells from these types of biosamples. These studies will greatly expand the
catalog of regulatory regions in the human genome. The rapid deposition of data into the ENCODE Data
Coordinating Center (DCC) will ensure quick public release. We expect the data and cell lines that are
generated by this Center will be a valuable resource for the broad scientific community.

## Key facts

- **NIH application ID:** 9858386
- **Project number:** 5UM1HG009442-04
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** MICHAEL P. SNYDER
- **Activity code:** UM1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $4,223,046
- **Award type:** 5
- **Project period:** 2017-02-01 → 2022-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9858386

## Citation

> US National Institutes of Health, RePORTER application 9858386, PRODUCTION CENTER FOR MAPPING REGULATORY REGIONS OF THE HUMAN GENOME (5UM1HG009442-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9858386. Licensed CC0.

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