# Appalachian Center for Cellular transport in Obesity Related Disorders (ACCORD) Genomics and Bioinformatics Core

> **NIH NIH P20** · MARSHALL UNIVERSITY · 2020 · $168,924

## Abstract

The Marshall University Genomics and Bioinformatics Core (GABC) will offer its services in support of the
proposed Appalachian Center for Cellular Transport in Obesity Related Disorders (ACCORD). This COBRE
application contains five projects each of which addresses the role of cellular transporters in the development
of obesity. Although their goals and specific aims vary, all five projects rely on at least one of the GABC
services for completion of their research goals; four of the investigator projects and a collaborative project will
require RNA-Seq expression profiling. The objective of the GABC is to enable the genomic and bioinformatics
research goals of this COBRE application and to assist other investigators in obtaining and analyzing genomic
data. The GABC will provide the following five services to COBRE investigators: (1) high throughput Next
Generation Sequencing (NGS) in support of RNA-Seq and other global genomic studies, (2) bioinformatic
methods and analyses for NGS projects, (3) automated Sanger DNA sequencing and RNA/DNA quality
assessment, (4) access to critical shared instruments including real-time thermal cyclers, Luminex 200 system,
Protein Simple Fluorimeter and SpectraMax plate reader and (5) workshops on NGS and bioinformatic
methods central to the COBRE research projects. The GABC business model includes a full-service plan of
operation for provision of NGS and other genomic services to the COBRE investigators. We anticipate that our
full service model will encourage COBRE and other investigators to adopt genomic approaches in their
research and that these interactions will promote the growth of GABC and genomic research in West Virginia.
The GABC will enable COBRE investigators to identify and characterize candidate pathways that help to
explain the role of transporters in the development of obesity. Our strategic plan and centralized expertise will
improve the efficiency of the research process in terms of improved access and reduced time and cost of
genomic data analysis. The long term impact of GABC participation will be to stimulate discovery of molecular
mechanisms in chronic diseases prevalent in West Virginia.

## Key facts

- **NIH application ID:** 9859412
- **Project number:** 5P20GM121299-03
- **Recipient organization:** MARSHALL UNIVERSITY
- **Principal Investigator:** Donald Anthony Primerano
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $168,924
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9859412

## Citation

> US National Institutes of Health, RePORTER application 9859412, Appalachian Center for Cellular transport in Obesity Related Disorders (ACCORD) Genomics and Bioinformatics Core (5P20GM121299-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9859412. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*