# Bioinflammation Core

> **NIH NIH P01** · AUGUSTA UNIVERSITY · 2020 · $291,943

## Abstract

BIOINFLAMMATION CORE SUMMARY CC, ERGUL
The projects in this Program Project Grant application focus on two key damage associated molecular patterns
(DAMPs), high mobility group box 1 (HMGB1) and mitochondrial (mt) DNA, activating the innate immune
response via their respective pattern recognition receptors (PPRs) TLR4 and TLR9 resulting in stimulation of a
number of cytokines in experimental animal models of hypertension. The Bioinflammation Core (Core C) is
structured to serve all three projects with centralized measurements of DAMPs, PRRs, immune cells and
downstream cytokines to facilitate the success of the individual projects and achieve the overall goals of this
Program Project. The secondary goal is to provide necessary services to enhance the synergy among projects.
Core C will be directed by Dr. Ergul and supported by Dr. Babak Baban. Both investigators have a long-
standing record of analyzing experimental and clinical specimens with a highly qualified staff. A centralized
Core is essential to the success of each project and the Program Project as a whole and offers the following
benefits:
 1. The coordination of sample preparation within the Bioinflammation Core C will benefit all Projects as
 Core C will optimize sample recovery and increase efficiency and rigor by allowing analysis of more
 samples in one run while providing blinded analyses of the samples.
 2. Common approach (in many cases identical methods and reagents) to measure the same markers
 across the projects will provide synergy, quality control and consistency among the projects.
 3. The measurement of primary and secondary DAMPs/PRRS in all Projects will cross cultivate the
 Projects and allow the development of new venues of investigation that otherwise would not have been
 possible with regular R01 applications.
 4. Higher numbers of measurements will be completed at a relatively lower cost with highly skilled
 research personnel.
 5. A close interaction with the Animal Models Core (Core B) will ensure proper collection and storage of
 specimens and increase reproducibility.

## Key facts

- **NIH application ID:** 9859434
- **Project number:** 5P01HL134604-04
- **Recipient organization:** AUGUSTA UNIVERSITY
- **Principal Investigator:** ADVIYE ERGUL
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $291,943
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9859434

## Citation

> US National Institutes of Health, RePORTER application 9859434, Bioinflammation Core (5P01HL134604-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9859434. Licensed CC0.

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