# Developmental Funds

> **NIH NIH P30** · UNIVERSITY OF COLORADO DENVER · 2020 · $90,232

## Abstract

DEVELOPMENTAL FUNDS (Core-065)
ABSTRACT
Overview and Goals: CCSG Developmental Funds are used with the goal of supporting the pursuit of new
scientific opportunities that, when properly selected, provide a significant boost to UCCC research activities. In
the current grant period, CCSG Developmental Funds have been used in combination with philanthropic funds
to promote strategic priorities of the UCCC in personalized medicine and population health by supporting two
projects. The first project is the Human Tumor Model-based Databank (HTMD). The HTMD has two goals: 1)
Assist UCCC members to establish their own Patient Derived Xenografts (PDX) and 2) house a central database
of all `omics information on PDX so evaluated that can be used for integrative analyses and queried remotely by
UCCC members seeking to study tumors with specific genomic, transcriptomic or proteomic markers. The
second project was aimed at nurturing growth of survivorship research at the UCCC via support for a staff
investigator, Jean Kutner MD, charged with promoting this area in our Cancer Prevention and Control (CPC)
program. Scientific Progress: With the goal of promoting translational research, UCCC leadership invested in
the development of the HTMD. In the last 5 years established over 250 unique patient derived xenografts (PDX).
Over 100 of these have been `omically profiled and are available for use and data query by UCCC members.
This success allowed us to obtain a CCSG administrative supplement both promoting this UCCC program and
benefitting the nation by contributing our PDXs to the NCI repository. The PDXs have been used in 24
publications and have lead or supported the initiation of clinical trials, some highlighted in our Program and SR
write-ups. In the same time frame, Kutner formed a UCCC Special Interest Group (SIG) for cancer survivorship
research that led to: 1) opening of eight survivorship research protocols; 2) a collaborative pilot program with the
Anschutz Health and Wellness Center (AHWC) to enroll cancer survivors in a supervised, exercise program to
measure the effect of an exercise regimen on quality of life and outcomes. A number of publications (33) and
grants ($1.35M in 2015) can be attributed to Kutner's leadership of the SIG. Future Directions: In the next 5
years we aim to use CCSG Developmental Funds to support pilot grants with cancer relevant organizations
across the UCCC consortium in a cost-shared manner with the objective to develop collaborative and synergistic
scientific projects that promote exceptional research across UCCC and leverage existing institutional strengths.
Projects will be selected based on their potential to exploit unique research ideas and capabilities and translate
these into innovations that are likely to lead to external funding and subsequent major advances in cancer
medicine. We will monitor and evaluate success of this pilot grant funding based on measurable outcomes
(publications, grants, trials). In summary,...

## Key facts

- **NIH application ID:** 9867660
- **Project number:** 5P30CA046934-32
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** Dan Theodorescu
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $90,232
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9867660

## Citation

> US National Institutes of Health, RePORTER application 9867660, Developmental Funds (5P30CA046934-32). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9867660. Licensed CC0.

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