# Genomics Shared Resource

> **NIH NIH P30** · UNIVERSITY OF COLORADO DENVER · 2020 · $159,142

## Abstract

GENOMICS SHARED RESOURCE (Core-298)
ABSTRACT
Overview: The Genomics Shared Resource (GSR) offers UCCC members high-quality and cost-effective
services and technical support for high-throughput genomic and proteomic investigation to study cancer
pathogenesis, therapeutics, genetic susceptibility and biomarker development. Equipment: The GSR houses
equipment to support DNA next-generation sequencing (NGS) (Illumina HiSeq 2000, 2500 and 4000, Illumina
MiSeq, and LifeTech IonPGM); DNA microarray analysis (Affymetrix GeneChip and GeneTitan systems; Illumina
iScan system; and Agilent SureScan Microarray system); single-cell genomics (Fluidigm C1; Juno; Access Array
and Biomark HD Systems); proteomics (Somalogic SOMAscan); and Affymetrix, Agilent and Illumina microarray
and sequencing software. Services: The GSR offers methodologies for quantitative assessment of
DNA/RNA/Protein including evaluation of human and murine cells harboring shRNA and CRISPR libraries UCCC
members have obtained from the Functional Genomics Shared Resource (FGSR). Our capabilities include
genome-wide analyses of DNA mutations and RNA expression from tissues to single cells. With these
capabilities, the GSR provides: 1) Genome-wide gene variations, gene expression and transcriptome analysis,
epigenetics and cytogenomics using NGS and gene microarrays; 2) Single cell genomic analysis; 3) Quantitate
selected genes/panels using real time PCR and digital PCR; 4) Proteomic quantitative analysis. Consultation
and Education: The GSR provides consultation for designing and analyzing reliable genomics and proteomic
experiments and helps keep members up to date as technology advances through seminars and hands-on
training. Management: The GSR is an institutional core managed by the UCCC, and is overseen by the
Associate Director for Basic Research. Use of Services: Since July 2011, the GSR has provided services to
313 investigators. Forty-seven percent of users (148) were UCCC members, representing all 6 Programs and
resulting in 155 peer reviewed publications. CCSG funding represents 5% of the annual operating budget. The
remaining support comes from the University of Colorado NIH funded CTSA (Colorado Clinical and Translational
Sciences Institute (CCTSI)) grant (4%), and user fees (91%). Future Directions: The GSR has three main future
directions that will enhance the SR and UCCC member cancer research: 1) Optimize single cell genomics; 2)
Enhance aptamer-based proteomics; 3) Adopt single molecule sequencing.

## Key facts

- **NIH application ID:** 9867666
- **Project number:** 5P30CA046934-32
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** Dan Theodorescu
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $159,142
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9867666

## Citation

> US National Institutes of Health, RePORTER application 9867666, Genomics Shared Resource (5P30CA046934-32). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9867666. Licensed CC0.

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