# Novel antimicrobials targeting MDR pathogens from animal microbial symbionts

> **NIH NIH U19** · UNIVERSITY OF WISCONSIN-MADISON · 2020 · $6,020,201

## Abstract

Project Summary
The discovery of new antimicrobials has failed to keep pace with the emergence of antimicrobial-resistant
infections, threatening public health. The overarching goal of the Wisconsin Antimicrobial Drug Discovery and
Development Center is to develop therapeutic countermeasures to tackle the antimicrobial resistance crisis.
Based upon our preliminary investigations using interdisciplinary, cutting-edge approaches, we hypothesize that
natural products from animal-microbe symbioses represent a new paradigm in antimicrobial drug discovery. The
Center proposes innovative conceptual and technical advances to overcome the critical bottlenecks of traditional
antimicrobial discovery to deliver therapeutic countermeasures for the drug-resistance epidemic.
Relevance
There is an ever-present and growing need to find novel, effective therapies for emerging resistant pathogens
that are becoming an increasing threat to the public health. The goals of the Center are to discover new
antimicrobial drugs. Our collaborative effort focuses on high-value natural products produced by under-
explored sources of biological and chemical diversity.

## Key facts

- **NIH application ID:** 9868267
- **Project number:** 5U19AI142720-02
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **Principal Investigator:** David R Andes
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $6,020,201
- **Award type:** 5
- **Project period:** 2019-04-01 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9868267

## Citation

> US National Institutes of Health, RePORTER application 9868267, Novel antimicrobials targeting MDR pathogens from animal microbial symbionts (5U19AI142720-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9868267. Licensed CC0.

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